Blood flow to leg muscles measured with phase-contrast MRI during supine exercise in patients with chronic heart failure.
Completed
- Conditions
- Chronic heart failurediminished pump-function of the heart.10019280
- Registration Number
- NL-OMON43173
- Lead Sponsor
- Maxima Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 26
Inclusion Criteria
Phase 1: Healthy volunteers in the age of 18-50 years that are able to perform maximal exercise test.
Phase 2: Patients with systolic heart failure (dilating or ischemic), NYHA-class II/III and ejection fraction <40%.
Exclusion Criteria
Phase 1: Cardiovascular disease and Orthopaedic, pulmonary, neuromuscular and other diseases limiting exercise capacity. Claustrophobia.
Phase 2: Recent myocardial infarction (< 3 months), decompensated heart failure, ventricular tachycardia or myocardial ischemia during exercise.
Orthopaedic, vascular, pulmonary, neuromuscular and other disease
limiting exercise capacity in a way that performing exercise tests is not feasible.
Claustrophobia.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Phase 1: Difference and agreement of blood flow (L/min) in the ascending (CO)<br /><br>en distal aorta (LBF) measured with PC-MRI in rest en during submaximal<br /><br>exercise between two days.<br /><br>Phase 2: Difference of DF (ratio) between patients with CHF and healthy,<br /><br>age-matched controls.</p><br>
- Secondary Outcome Measures
Name Time Method <p>N.A.</p><br>