Blood volume changes in skeletal muscle.
- Conditions
- vascular endothelium dysfunction, dysfunction arteries, skeletal muscle, blood volume changes.
- Registration Number
- NL-OMON24988
- Lead Sponsor
- Máxima Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Written informed consent Age 18-50 years. Able to perform a maximal exercise test.
Exclusion Criteria
Subjects with risk of adverse events according to abnormal findings in physical examination or the Lausanne questionnaire. Orthopaedic,cardio-vascular, pulmonary, neuromuscular and other diseases limiting exercise capacity.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reproducibility: Difference and agreement (bias and limits of agreement) of changes in blood volume assessed by power Doppler in the vastus lateralis muscle during maximal and submaximal exercise on two separate days.
- Secondary Outcome Measures
Name Time Method Validity: <br /><br>- Correlation between changes in power Doppler-signal in the musculus vastus lateralis and changes in blood flow in the afferent artery measured with pulsed wave Doppler during exercise. <br /><br>- Correlation between changes in total hemoglobulin measured with near infrared spectroscopy and changes in Power Doppler-signal during exercise.