Determination of blood volume and hemoglobin mass using the optimised carbon monoxide rebreathing method in clinical patients - cardiac failure or situation post cardiac transplant
- Conditions
- I50.1D63.8Left ventricular failureAnaemia in other chronic diseases classified elsewhere
- Registration Number
- DRKS00006078
- Lead Sponsor
- niversitätsklinik FreiburgInstitut für Arbeits- und Bewegungsmedizin
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 127
Main study population (cross-sectional analysis): chronic cardiac failure with at least a moderately reduced LV function (EF<45%), of various origin, e.g. ischemic, dilated, inflammatory. Or preserved LV function when situation post heart transplant.
Phycial acitivity group (longitudinal analysis): as above but with a weekly physical activity of at least 150min, e.g. through participation in cardiac sports group, nordic walking, strolling
- patients with acute coronary syndrome without intervention - life expectation of less than one year because of a non-cardial disease - current onconlogic disease - acute infection (e.g. pneumonia) - evidence for acute transplant failure - chronic inflammatory diseases - relevant chronic kidney disease of non cardiac origin - anemia of origin other than cardiac e.g. chronic intestinal hemorrhage - [?Hb] < 8g/dl - current use of erythropoietic growth factors - patients featuring a lung function that does not allow participation in a rebreathing procedure from a clinical aspect - people that cannot participate in the study because of a lack of compliance, based on the judgement of the study doctors - chronic alkohol or drug abuse - those who are not able or not willing to give an informed consent to participate in the study
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hemoglobin mass measured using the optimised carbon monoxide rebreathing method in patients with different stages of left ventricular failure
- Secondary Outcome Measures
Name Time Method - Influence of physical activity on hemoglobin mass.<br>- Relation between hemoglobin mass and FBC, Iron status<br>