A Retrospective Study on Comparing Different Cervical Cancer Screening Methods and Factors Linked to HPV Infection in a Tertiary Cancer Clinic

Not yet recruiting

Conditions: Neoplasms,

Registration Number: CTRI/2025/04/084075

Lead Sponsor: NA

Brief Summary: Cervical cancer is a major public health problem worldwide, being the fourth most common cause of cancer and death among women. About one in every 70 women globally develops cervical cancer at some point in her life, with India accounting for a significant portion of the deaths from this disease. There are three main ways to screen for cervical cancer: Pap smear, HPV DNA testing, and visual inspection with acetic acid

Early detection of HPV infection and precancerous lesions through regular screenings can significantly reduce the incidence of cervical cancer and improve treatment outcomes. By identifying risk factors associated with HPV infection and CIN, targeted preventive measures and interventions can be implemented more effectively. Overall, this study contributes to the global effort to combat cervical cancer by informing healthcare policies and resource allocation strategies based on evidence-based screening methods.

This study aims to evaluate the effectiveness of cervical cancer screening methods by comparing the accuracy of different screening methods by analyzing the medical records of 26,400 women who underwent screenings between 2008 and 2023 at the Department of Preventive Oncology.

These findings will provide valuable insights into the performance of each screening method, aiding healthcare providers in selecting the most effective approach, especially in resource-constrained settings.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: Female

Target Recruitment: 26400

Inclusion Criteria

Women aged 18 years above Women who Underwent cervical cancer screening by VIA, cytology and HPV DNA test Women Underwent diagnostic evaluation by Colposcopy.

Exclusion Criteria

Inadequate data despite the attempt will be excluded from the study.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Prevalence and Determinants Of HPV infection & CIN:	12 Months
a. proportion of screened women testing positive for HPV infection.	12 Months
b. Prevalence of different grades of cervical Intraepithelial Neoplasia (CIN1, CIN2, CIN3)	12 Months
2. HPV Genotype Distribution and Association with Cervical Lesions:	12 Months
a. Proportion of HPV-positive women with abnormal cytology results.	12 Months
b. association between HPV genotype and cytological abnormalities such as ASCUS,LSIL and HSIL	12 Months
c. Association of Socio-demographic, clinical, and behavioral factors with HPV infection and CIN.	12 Months
a. Frequency of different HPV genotypes detected.	12 Months
b. association of specific high-risk HPV genotypes with histologically confirmed precancerous (CIN2/3) and cancerous lesions.	12 Months
3. Association Between HPV infection and cytological abnormalities:	12 Months

Secondary Outcome Measures

Name	Time	Method
1. Comparison of Cervical Cancer Screening Methods & Diagnostic Accuracy:	a)Sensitivity, specificity, positive predictive value (PPV), and negative predictive value

Trial Locations

Locations (1): Tata Memorial Hospital
🇮🇳
Mumbai, MAHARASHTRA, India
Tata Memorial Hospital
🇮🇳Mumbai, MAHARASHTRA, India
Dr Sharmila Pimple
Principal investigator
09223207939
pimplesharmila@gmail.com