An Open-label, Multicenter, Non-Comparative Phase II Study of the Combination of Intravenous Topotecan and Gemcitabine Administered Once Weekly for Three Weeks Every 28 Days as Second-line Treatment in Patients With Recurrent Platinum Sensitive Ovarian Cancer

GlaxoSmithKline1 site in 1 country75 target enrollmentDecember 2002

ConditionsPeritoneal Cancer Ovarian Cancer Neoplasms, Ovarian Fallopian Tube Cancer

DrugsTopotecan Gemcitabine

Overview

Phase: Phase 2
Intervention: Not specified
Conditions: Peritoneal Cancer
Sponsor: GlaxoSmithKline
Enrollment: 75
Locations: 1
Primary Endpoint: response rate
Status: Completed
Last Updated: 8 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This research study was designed to determine the effectiveness of the drug, topotecan, given intravenously (into a vein) together with the drug gemcitabine in patients with recurrent platinum-sensitive ovarian, fallopian or primary peritoneal cancer, as well as tumors of mixed mullerian origin. Additional purposes are to determine the long term outcome and side effects of this combination treatment.

Since topotecan and gemcitabine have different mechanisms of action, the combination of these 2 drugs may provide better results than either drug alone. Prior studies suggest that the combination of topotecan and gemcitabine improves the effects on the tumor and also appeared to be well tolerated.

Registry

clinicaltrials.gov

Start Date

December 2002

End Date

September 2004

Last Updated

8 years ago

Study Type

Interventional

Sex

Female

Investigators

Sponsor

GlaxoSmithKline

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Have had one prior platinum-based chemotherapy regimen for the treatment of primary disease.
•At least 4 weeks since last surgery or radiation therapy.
•Must have had a treatment-free interval of greater than 6 months following response to platinum.
•ECOG performance status of 0,1, or 2.

Exclusion Criteria

•Women of child-bearing potential that do not practice adequate contraception.
•Pregnant or lactating.
•Received more than one primary chemotherapy regimen.
•Concomitant or previous malignancies with the exception of adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, incidental carcinoid, or other cancer from which the patient has been disease free for 5 years.
•Active uncontrolled infection requiring antibiotics.
•Concurrent severe medical problems unrelated to the malignancy which would limit full compliance with the study.
•Received radiation to more than 10% of bone.
•Prior treatment with topotecan or gemcitabine.
•Hypersensitivity to camptothecin or nucleoside analogues.
•Use of an investigational agent within 30 days.