Establishment and Characterization of Patient-Derived Non-Small Cell Lung Cancer Xenografts and Cell Cultures

• Conditions: Non Small Cell Lung Cancer
• Interventions: Procedure: Xenografts and cell cultures

• Registration Number: NCT01130571
• Lead Sponsor: National University Hospital, Singapore

Brief Summary

Xenografts and cell cultures provide sufficient material for analyses at the protein, RNA and DNA level. Patient derived NSCLC xenografts and cell lines are available but none however are Asian in origin. Given the emerging evidence to suggest inter-ethnic differences in NSCLC biology, new models of preclinical drug evaluation should be designed and validated using Asian tumors. Furthermore, such models will allow studies of biological mechanisms of sensitivity and/or resistance and also the study of dynamic regulations under standardized conditions in the Asian context.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-05-24
• Study First Submitted QC: 2010-05-25
• Study First Posted: 2010-05-26
• Study Start: 2011-09
• Status Verified: 2014-01
• Last Update Submitted: 2014-01-21
• Last Update Posted: 2014-01-22
• Primary Completion: 2014-12
• Study Completion: 2014-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Patients aged 21 years and above.
• Undergoing a surgical resection of tumor as part of clinical management

Exclusion Criteria

• Patient or legally acceptable representative unable to provide consent patient in the judgement of the study investigator, is medically unsuitable for this study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Non-Small Cell Lung Cancer	Xenografts and cell cultures	-

Trial Locations

Locations (1)

National University Hospital; 🇸🇬 Singapore, Singapore