Conditioned Pain Modulation With Ultra-Brief Conditioning Stimulus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- worst pain ratings of foot only
研究概览
简要总结
This "pain reduces pain" study looks at how the brain reduces pain when a person feels two painful sensations at the same time. There is considerable evidence that the brain can "turn down" pain using natural endogenous pain-control systems. The current CPM study measures whether attentional processes can also make a measurable contribution to pain inhibition alongside neurochemical mechanisms.
详细描述
Conditioned pain modulation (CPM) is a natural process where feeling pain in one part of the body (e.g., a conditioning stimulus to the wrist) can reduce pain felt in another part of the body (a test stimulus to the foot). There is considerable evidence from both animal and human studies that the painful conditioning stimulus can stimulate the brain to activate neurochemical pain-control pathways (e.g., endogenous opioids), which are believed to take 30-120 seconds to fully engage. The current CPM study measures whether attentional processes can also make a measurable contribution to pain inhibition alongside neurochemical mechanisms.
Primary measures: Graphic ratings scale "worst pain" ratings.
The primary measure of the current study graphic ratings scales (worst pain ratings) will measure how much pain participants feel on their foot during foot only (test stimulus), vs. how much pain participants feel on their foot (test stimulus during simultaneous foot (test stimulus) + wrist (conditioning stimulus).
The current investigators predict that pain (e.g., the conditioning stimulus) naturally demands attention and can pull attention away from the original pain source (the test stimulus), resulting in CPM-like reductions in pain of the test stimulus.
Secondary measure #1. Cognitive measures are introduced in the current study, to quantify how much (if at all) the conditioning stimulus reduces pain of the target stimulus via attentional mechanisms. Participants estimate what percentage of their attention was directed to their foot (the test stimulus) during foot only vs. during foot + wrist (test + conditioning stimulus). This will measure whether the conditiioning stimulus to the wrist reduces how much attention participants focus on their foot. Analyses will also measure whether the amount of attention shift away from the foot (via participants; subjective ratings) is correlated with CPM robustness (reduction in pain of foot during duel stimulation).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Only University of Washington students in eligible psychological courses are
- •eligible. General public is not eligible.
- •Enrolled psychology students fluent in English,
- •Age ≥18 y, able to follow instructions.
排除标准
- •Seizure history,
- •Migraines,
- •Diabetes,
- •Extreme pain insensitivity,
- •Motion sickness,
- •or prior participation in this protocol.
研究组 & 干预措施
Single pain stimulus
test pain stimulus alone
干预措施: test stimulus (Behavioral)
dual pain stimuli
simultaneous foot (test stimulus + wrist (conditioning stimulus)
干预措施: conditioned pain modulation (Behavioral)
结局指标
主要结局
worst pain ratings of foot only
时间窗: rated immediately after each thermal stimulus
graphic rating scale from 0 (no pain) to 10 (excruciating pain)
worst pain on graphic rating scale during test+conditioning stimulus
时间窗: measured immediately after the stimuli
graphic rating scale from 0 (no pain) to 10 (excruciating pain)
次要结局
- % of attention devoted to foot during test stimulus only (0-100% scale)(rated immediately after the stimuli)
- Divided attention during test stimulus + conditioning stimulus (% correct, 100% is highest )(Day 1, during the thermal stimuli)
- % of attention devoted to foot during test+conditioning stimuli (0-100% scale)(rated immediately after the thermal stimuli)
- Divided attention during test stimulus only (% correct, where 100% is highest accuracy)(Day 1, during the thermal stimulus)
研究者
Hunter Hoffman
Research Scientist
University of Washington