The effect of dietary nitrate on exercise in hypoxia

Imperial College0 个研究点目标入组 90 人开始时间: 2015年7月14日最近更新: 2023年8月2日

适应症

试验速览

2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34853156/ Results for COPD group (added 03/12/2021)

•Current inclusion criteria as of 18/07/2023:
•1. Adult patients with GOLD I-IV COPD who require ambulatory oxygen because of exertional desaturation
•2. Adult patients with IPF who require ambulatory oxygen because of exertional desaturation
•3. Adult patients with pulmonary hypertension who require ambulatory oxygen because of exertional desaturation
•4. Adults with a history of COVID-19 and persisting breathlessness at least 3 months following the acute illness and evidence of pulmonary vascular abnormalities (abnormal gas transfer defined as a TLco _____
•Previous inclusion criteria as of 11/01/2023:
•1. Adult patients with GOLD I-IV COPD who require ambulatory oxygen because of exertional desaturation
•2. Adult patients with IPF who require ambulatory oxygen because of exertional desaturation
•3. Adult patients with pulmonary hypertension who require ambulatory oxygen because of exertional desaturation
•4. Adults with a history of COVID-19 and persisting breathlessness at least 3 months following the acute illness and evidence of pulmonary vascular abnormalities
•Previous inclusion criteria:
•1. Adult patients with GOLD I-IV COPD who require ambulatory oxygen because of exertional desaturation
•2. Adult patients with IPF who require ambulatory oxygen because of exertional desaturation
•3. Adult patients with pulmonary hypertension who require ambulatory oxygen because of exertional desaturation

•1. Clinically unstable patients (within one month of exacerbation)
•2. Significant comorbidity limiting exercise tolerance
•3. Significant renal impairment (estimated glomerular filtration rate (eGFR) <50 ml.min-1)
•4. Hypotension (systolic blood pressure <100 mmHg)
•5. Pregnancy
•6. Use of nitrate based medication or PDE5 inhibitors such as sildenafil

发起方

Imperial College