The Performance of Renal Doppler Ultrasound in Predicting Outcome of Dialysis Weaning

Completed

• Conditions: Acute Kidney Failure Stage 3; Acute Kidney Injury
• Interventions: Other: Dialysis weaning

• Registration Number: NCT04622384
• Lead Sponsor: Johan Fridolf Hermansen

Brief Summary

Acute kidney injury (AKI) is a frequent problem in the intensive care unit (ICU) affecting more than 50 % of patients. AKI is associated with several adverse outcomes, including increased mortality and increased length of ICU- and hospital stay, in particular in patients requiring Renal Replacement Therapy (RRT).

Choosing the optimal time for attempting liberation from RRT is still unclear. With this study, we will describe the ability of renal ultrasound in predicting the outcome of dialysis weaning.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-10-26
• Study First Submitted QC: 2020-11-05
• Study First Posted: 2020-11-10
• Study Start: 2021-01-01
• Primary Completion: 2023-03-01
• Study Completion: 2023-03-01
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-20
• Last Update Posted: 2024-03-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

• All patients ≥ 18 years admitted to the ICU, Aarhus University Hospital who are treated with dialysis as continuous renal placement therapy (CRRT) and planned to undergo dialysis weaning

Exclusion Criteria

• Insufficient ultrasonographic imaging of the kidneys
• Known morphological kidney disease
• Previous need of chronic RRT
• Prior participation in the study
• Need of extracorporeal membrane oxygenation (ECMO) or other heart assist device

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ICU patients	Dialysis weaning	Patients who are treated with dialysis as CRRT and planned to undergo dialysis weaning.

Primary Outcome Measures

Name	Time	Method
Dialysis weaning	7 days	If discontinuation of Dialysis is successful or not. Successful dialysis weaning is defined as no renal replacement therapy (RRT) required within the first 7 days after stopping continuous renal replacement therapy (CRRT) and non-successful weaning as the need for RRT within the first 7 days.

Secondary Outcome Measures

Name	Time	Method
Renal Doppler arterial Resistive Index (RI)	Measured at the beginning of weaning and after 6 hours.	Measured in the interlobar vessels
Renal Doppler Venous Impedance Index (VII)	Measured at the beginning of weaning and after 6 hours.	Measured in the interlobar vessels
Portal vein Doppler Pulsatility Fraction PF)	Measured at the beginning of weaning and after 6 hours.	Measured in the interlobar vessels
Urine Output	4 days
Renal Doppler Renal Venous Stasis Index (RVSI)	Measured at the beginning of weaning and after 6 hours.	Measured in the interlobar vessels
Urine Creatinine Clearance	4 days

Trial Locations

Locations (1)

Aarhus University Hospital, Department of Anaesthesiology; 🇩🇰 Aarhus, Denmark