RDRI and NGAL in Acute Kidney Injury in Abdominal Surgery

Completed

• Conditions: Acute Kidney Injury

• Registration Number: NCT05929573
• Lead Sponsor: Antalya Training and Research Hospital

Brief Summary

Acute kidney injury (AKI), which can occur after major surgeries, leads to increased morbidity and mortality if not detected and managed promptly. In clinical practice, serum creatinine and urine output values of patients are monitored to detect AKI, but these parameters can cause delays in diagnosis. Additionally, studies have been conducted on biomarkers such as Neutrophil Gelatinase-Associated Lipocalin (NGAL) and cystatin C in recent years, but definitive results have not been achieved.

Renal Doppler Resistive Index (RDRI) is a non-invasive index believed to reflect renal vascular perfusion. RDRI measurement is a repeatable, inexpensive, and easy-to-apply technique. RDRI has been found to be associated with AKI in conditions such as renal dysfunction, hypertension, and post-traumatic hemorrhagic shock. Furthermore, due to the impact on renal perfusion in patients undergoing major surgery, RDRI, which reflects renal vascular resistance, can serve as an indicator of kidney perfusion.

The aim of this study is to test the hypothesis, 'Does measuring postoperative RDRI in major abdominal surgery cases yield higher sensitivity and specificity values in detecting acute kidney injury compared to NGAL?'

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-06-25
• Study First Submitted QC: 2023-06-25
• Study Start: 2023-07-01
• Study First Posted: 2023-07-03
• Primary Completion: 2023-12-31
• Status Verified: 2024-07
• Study Completion: 2024-07-20
• Last Update Submitted: 2024-07-29
• Last Update Posted: 2024-07-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

• ASA I-III,
• Patients undergoing elective major abdominal surgery

Exclusion Criteria

• Chronic kidney failure,
• Using nephrotoxic drugs,
• Patients with a history of kidney transplantation or nephrectomy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Renal Doppler Resistive Index	Postoperative 4th hour	Renal Doppler Resistive Index will be measured at the 4th hour after major abdominal surgery.
Plasma NGAL Level	Postoperative 4th hour	From patients undergoing major abdominal surgery, a blood sample will be taken at Postop 4th Hour for serum NGAL analysis

Trial Locations

Locations (1)

Antalya Training and Research Hospital; 🇹🇷 Antalya, Turkey