Association Between Renal Resistive Index(RRI) and AKI(Acute Kidney Injury) in Cardiac Surgery Patients With Cardiopulmonary Bypass (CPB)

Not yet recruiting

• Conditions: Acute Kidney Injury; Renal Resistive Index
• Interventions: Procedure: Renal interlobar artery US; Procedure: Renal inter-lobular artery US

• Registration Number: NCT06464666
• Lead Sponsor: Yonsei University

Brief Summary

AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity. The conventiional marker for detecting AKI is serum creatinine, however, which has many limits. RRI(Renal Resistive Index) is a non-invasive test measured by ultrasound and could be a useful tool to evaulate renal insult in the early phase. Early detection of renal insult and prevention of progression to AKI can contribute to reduing mortality and morbidity in cardiac surgical patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-06
• Study First Submitted: 2024-06-10
• Study First Submitted QC: 2024-06-10
• Last Update Submitted: 2024-06-10
• Study First Posted: 2024-06-18
• Last Update Posted: 2024-06-18
• Study Start: 2024-07-01
• Primary Completion: 2025-06-25
• Study Completion: 2025-06-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• Aged 19 years and older scheduled for cardiac surgery using CPB

Exclusion Criteria

• Emergency opeartion, pre-operative shock status requiring vasopressor or inotropics, s/p kidney transplant patients, CKD stage 4 and 5 patients, patients who have renal artery stenosis or history of renal artery stent implantation, patients who have ascites with Child-Pugh classification B or C, In case of CPB weaning failure, In case of poor lung function and PaO2 or PaCO2 cannot be maintained within normal range.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
RRI positive group	Renal interlobar artery US	RRI value higher than 0.7 measured by renal interlobar artery US
RRI negative group	Renal inter-lobular artery US	RRI value lower than 0.7 measured by renal interlobar artery US

Primary Outcome Measures

Name	Time	Method
post-operative AKI incidence	within first 1 week after surgery	The definition of AKI refers to Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury.

Secondary Outcome Measures

Name	Time	Method
Major adverse kidney outcome (MAKE) 30	within first 1 month after surgery	MAKE30 includes new dialysis, eGFR decrease more than 25% from the baseline, and mortality