skin aging treatment by unani formulation.

Phase 2

Not yet recruiting

Conditions: Other skin changes due to chronicexposure to nonionizing radiation,

Registration Number: CTRI/2021/01/030852

Lead Sponsor: National institute of unani medicine

Brief Summary: Skin aging is a complexbiological process influenced by a combination of intrinsic and extrinsicfactors. Extrinsic aging is influenced by factors such as smoking, excessivealcohol consumption, poor nutrition, and chronic exposure to the sun. Wrinklingand pigmentary changes are directly associated with photo-aging. Asian skintends to tan more and burn less, which means that chronic UV exposure tends toproduce more pigmentation-related problems. There are several syntheticskincare cosmetics existing in the market to treat premature aging and theyhave so many adverse reactions too. Therefore a cheap, effective and safealternative is needed for the prevention of skin ageing. For the prevention ofskin aging, Unani physicians recommend the use of *Jaali, mohammir* and *Mohsin allon* drugs. In which *aarad e baqla,aarad e jau, aarad e nakhud, aarad e masoor, tukhm e turb, khardal, haldi* and*kateera* are selected for the study.They have protein, fat, vitamin B complex, vitamin E, Mn, Cu, Zn, etc. as theirmain constituents. These chemical constituents contribute to photoprotection byincreasing epithelialisation, smoothing the skin and stimulating collagensynthesis. The drugs will be given in powder form, *Kateera* will be powdered separately and mixed into the wholepowder. Subjects will be advised to take 15 gm powder and mix into milk to forma uniform paste then applied it on the face once a day for 2 month. On theother hand control group will be given Tretinoin 0.025% cream & appliedlocally once a day for 2 months.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 82

Inclusion Criteria

Having fine lines, wrinkles, hyper pigmentation 2.
Moderate to advance facial skin aging 3.
No known medical condition 4.
Subject must sign a written informed consent.

Exclusion Criteria

Subjects who are taking any medication which interfere with the test result.
Having history of skin cancer, melanoma , lupus, psoriasis, connective tissue disease.
Pregnant or planning pregnancy during study period, lactating, had given birth during the previous 6 months.
Acute or chronic allergy or history of hypersensitivity to cosmetics.
Smokers, having psychiatric disorder , hormone related and GIT disease.
Uncontrolled metabolic illness (e.g. diabetes mellitus, hypertension).
Having any skin procedure in previous 6 months (dermabrasion, chemical peel, botulinum toxin type A injection).
Subjects using anti aging skin care products.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
2.Hyperpigmentation.	2 month
1.Hydration.	2 month
3.Dullness and roughness.	2 month
4.Coarse wrinkles.	2 month

Secondary Outcome Measures

Name	Time	Method
1.Fine lines.	2.thickness.

Trial Locations

Locations (1): National Institute of Unani Medicine
🇮🇳
Bangalore, KARNATAKA, India
National Institute of Unani Medicine
🇮🇳Bangalore, KARNATAKA, India
Dr Chand Bibi
Principal investigator
8630103130
ghanichand484@gmail.com