Effect of CPAP on Blood Pressure in Patients With Sleep Apnea and Refractory Hypertension

Not Applicable

Completed

• Conditions: Refractory Arterial Hypertension; Obstructive Sleep Apnea
• Interventions: Device: CPAP; Device: Control

• Registration Number: NCT00863135
• Lead Sponsor: Corporacion Parc Tauli

Brief Summary

The purpose of this study is to determine the effects of CPAP treatment on blood pressure in patients with sleep apnea syndrome (SAS) and refractory arterial hypertension (RAH).

Also, some of the mechanisms mediating SAS and RAH (systemic inflammation, oxidative stress, sympathetic hyperactivity) will be analyzed.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-12
• Study First Submitted: 2009-03-16
• Study First Submitted QC: 2009-03-16
• Study First Posted: 2009-03-17
• Primary Completion: 2016-07
• Study Completion: 2016-07
• Status Verified: 2017-02
• Last Update Submitted: 2017-02-07
• Last Update Posted: 2017-02-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 68

Inclusion Criteria

• refractory arterial hypertension and sleep apnea with apnea-hypopnea index over 15

Exclusion Criteria

• excessive sleepiness
• professional drivers
• secondary arterial hypertension

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Continuous Positive Airway Pressure	CPAP	nocturnal continuous positive airways pressure
Control	Control	Waiting list,3 months without any change in their treatment, come into the CPAP procedure after that time

Primary Outcome Measures

Name	Time	Method
24 hours blood pressure monitoring	basal and after three months of CPAP treatment

Secondary Outcome Measures

Name	Time	Method
oxidative stress and inflammatory mediators	basal and after three months of CPAP treatment

Trial Locations

Locations (1)

Corporacio Parc Tauli; 🇪🇸 Sabadell, Barcelona, Spain