Prevalence of Barrett's Esophagus in Adolescents and Young Adults With Esophageal Atresia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 20
- 主要终点
- presence of gastric and / or intestinal metaplasia diagnosed at histology
研究概览
简要总结
The frequency of Barrett's esophagus (BE) has increased in adults in the last decades, but BE is rare in children. Esophageal atresia (EA), the most common congenital anomaly affecting the esophagus, predisposes the patient to severe and prolonged gastroesophageal reflux disease. Because gastroesophageal reflux disease plays a major role in the development of BE by causing repeated mucosal damage, development of BE is a concern even in children and young adults in this specific population. The aim of this study is to assess the prevalence of BE (gastric and/or intestinal metaplasia) in a population of adolescents/young adults who had been treated for EA in early infancy. All eligible patients received upper gastrointestinal endoscopy under general anesthesia with standardized esophageal staged biopsies. Histological suspicion of metaplasia was confirmed centrally.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 15 Years 至 19 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Medical history of esophageal atresia (all types, Ladd's classification)
排除标准
- •No medical history of esophageal atresia
- •Non acceptance to participate from the patient and/or his parents
- •esophageal atresia treated with esophageal replacement (e.g., coloplasty, gastric transposition)
结局指标
主要结局
presence of gastric and / or intestinal metaplasia diagnosed at histology
时间窗: during 2 hours of the endoscopy exam
Prevalence of Barrett's esophagus (gastric and/or intestinal metaplasia) in adolescents treated for esophageal atresia
次要结局
- evaluation of the nutritional status(during the single visit scheduled, the day of endoscopy. This periode is corresponding at a day hospitalization (less than 12 hours in the day))
- presence of esophagitis or anomalies at the anastomotic stage diagnosed at histology(during 2 hours of the endoscopy exam)
- evaluation of actual symptoms and treatment of gastroesophageal reflux disease(during the single visit scheduled, the day of endoscopy. This periode is corresponding at a day hospitalization (less than 12 hours in the day))
- evaluation of actual other symptoms (respiratory, dysphagia)(during the single visit scheduled, the day of endoscopy. This periode is corresponding at a day hospitalization (less than 12 hours in the day))