RBR-3z3w3n
Not yet recruiting
未知
Analysis of the clinical profile of diabetic patients with periodontitis before and after probiotic therapy
niversidade de São Paulo0 sitesMay 22, 2020
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Diabetes Mellitus
- Sponsor
- niversidade de São Paulo
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Presence of at least 15 natural teeth, excluding third molars and teeth indicated for extraction; diagnosis of generalized stage III grade C periodontitis, with more than 30% of the sites with probing depth and clinical level of insertion greater than or equal to 4 mm and bleeding on probing of at least 30% of the teeth; presence of type II diabetes mellitus diagnosed at least 5 years ago, with glycated hemoglobin levels between 7% and 11%, treatment with diet and supplementation with insulin or hypoglycemic agents; presence of a good state of general health with the exception of diabetes mellitus.
Exclusion Criteria
- •Presence of other systemic conditions, with the exception of diabetes mellitus, which can affect the progression of periodontitis or the response to its treatment; long\-term administration of anti\-inflammatory or immunosuppressive medication; periodontal treatment and / or use of antimicrobials in the last 6 months; use of probiotics in the last 6 months; continuous use of mouthwashes containing antimicrobial agents in the last 6 months; need for prophylactic antibiotic therapy for routine dental procedures; extensive prosthetic rehabilitation; tobacco consumption in the last 5 years; pregnancy and lactation; diabetic complications, such as nephropathy, neuropathy, and peripheral cardiovascular and vascular diseases.
Outcomes
Primary Outcomes
Not specified
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