Does resistance training exercise help prevent frailty and loss of independence for older people with insulin treated diabetes? The EXPLODE Trial

Not Applicable

• Conditions: Type 1 diabetes and type 2 diabetes treated with exogenous insulin; Nutritional, Metabolic, Endocrine; Diabetes mellitus

• Registration Number: ISRCTN13193281
• Lead Sponsor: ewcastle upon Tyne Hospitals NHS Foundation Trust

Brief Summary

2021 Protocol article in https://pubmed.ncbi.nlm.nih.gov/34880011/ (added 10/12/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-08-03
• Last Update Posted: 30 January 2023
• Study Completion: 2025-04-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Aged =60 years
2. Rockwood Clinical Frailty Score of 3 or 4
3. Diagnosis of type 1 or type 2 diabetes mellitus, or age and frailty matched non-diabetic control

Exclusion Criteria

1. Myocardial infarction in the last 12 months
2. Stroke in the last 12 months
3. Renal failure in the last 12 months
4. Liver disease in the last 12 months
5. Inability to give consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Feasibility of carrying out a larger trial, measured using recruitment and retention rate, and the acceptability of intervention of resistance exercise as assessed using an interview of a subset of participants at baseline and 5 weeks