A clinical trial to Study the effects of oral tofacitinib and azathioprine in chronic actinic dermatitis

Not Applicable

Conditions: Health Condition 1: L562- Photocontact dermatitis [berloquedermatitis]

Registration Number: CTRI/2023/03/051181

Lead Sponsor: Krishna Vishwa Vidyapeeth

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1. Patients with Clinical diagnosis of chronic actinic dermatitis including:

Actinic Prurigo

Actinic cheilitis

Lichenoid photodermatitis

Photoallergic dermatitis

Phytophotodermatitis

Actinic reticuloid

2. Age group more than 18 years of age.

3. The patient should have given written consent before the investigations and starting the drug.

4. The patient should be able and willing and fit, in the view of the investigator, to comply with all study procedures

Exclusion Criteria

A .Patients with acute photodermatitis.

B. Patients allergic to tofacitinib or azathioprine.

C. Patient with cardiac diseases or hematological diseases (including angina, coronary artery disease, recent or acute myocardial infarction, pericardial effusion,anemia,coagulation disorders)

D. Patients with cerebrovascular diseases

E.Patients with deranged liver and kidney function.

F. Patients with recent infections.

G. Patient with positive mantoux test.

H.Patients with a recent or past history of tuberculosis

I.Patient with a positive Interferon Gamma Release Assay (IGRA) test.

J.Patients with a history of acute phototoxic diseases.

K.Phototoxic rash related to some drug.

L.Patients with Low Thiopurine Methyl Transferase(TPMT) value ( < 0.5 U). M.Pregnant,lactating or women of child bearing age group with incomplete family. N.Patients with positive HIV,HCV or HbsAg.

O.Patients having diabetes mellitus.

P.Patients with any immunocompromised conditions.