Comparison betwwen effectiveness of oral Tofacitinib Vs oral Cyclosporine in the treatment of prurigo nodularis: An accessor-blinded randomised controlled trial - NI

IMS and SUM Hospital0 个研究点目标入组 0 人开始时间: 待定最近更新: 2024年8月19日

研究概览

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•Patients with more than equal to 18 years age group, diagnosed clinically and histopathologically as prurigo nodularis and having with severe pruritus for at least 3 months
•Severe pruritus was defined as a mean score of at least 7 points over the previous week for the worst daily intensity of pruritus on the numerical rating scale
•Patients having an active health insurance.

•1.chronic pruritus due to conditions other than PN;
•2.use of antihistamines, steroids, other systemic antipruritic therapies, or immunosuppressants 1 to 2 weeks before the baseline visit;
•3.recent phototherapy;
•4.use of medications known to induce pruritus; serum creatinine level higher than 2.4 mg/dL;
•5.aspartate transaminase or alanine transaminase levels more than 2 times the upper limit of normal;
•6.Active infection(HIV, Tuberculosis, Hepatitis b,etc)
•7.Latent tuberculosis
•8.Known case of dyslipidemia
•9.Prior history of MI, cerebral ischaemia and transient ischaemic attack.
•10.History of prior venous thromboembolism, major surgery and immobolisation in past 6 months.
•11.On concurrent oral contraceptive pills or hormone replacement therapy.
•12.Patient have any inherited coagulation disorder.
•13.Pregnant and lactating females

发起方

IMS and SUM Hospital