onger-term effects of a novel nutritional combination on muscle insulin sensitivity and mitochondrial function, and vascular function in abdominally obese subjects - Nutritional supplementation and insulin sensitivity

niversiteit Maastricht0 个研究点目标入组 88 人开始时间: 待定最近更新: 2024年4月15日

试验速览

暂无简介。

•- Aged between 50-70 years
•- Men and postmenopausal (two or more years after last menstruation) women
•- Waist circumference for men > 102 cm and for women > 88 cm (abdominally obese)
•- Impaired fasting glucose concentrations (between 5.6 - 7.0 mmol/L in
•accordance with the American Diabetes Association guidelines for prediabetes)
•at two screening visits
•- Fasting serum total cholesterol < 8.0 mmol/L
•- Stable body weight (weight gain or loss < 3 kg in the past three months)
•- Willingness to give up being a blood donor from 8 weeks before the start of
•the study, during the study and for 4 weeks after completion of the study
•- No difficult venipuncture as evidenced during the screening visit
•- Willingness to give up the use of antibacterial mouth wash or antibacterial
•toothpaste, chewing-gum and tongue-scraping during the study

•- Current smoker, or smoking cessation < 12 months
•- Diabetic patients
•- Familial hypercholesterolemia
•- Abuse of drugs
•- More than 3 alcoholic consumptions per day
•- Use of dietary supplements known to interfere with the main study outcomes as
•judged by the principal investigators
•- Use of anticoagulant drugs or drugs to treat blood pressure, lipid/glucose
•- Use of an investigational product within another biomedical intervention
•trial within the previous 1-month
•- Intolerance or allergy to the ingredients of the intervention products
•- Severe medical conditions that might interfere with the study, such as
•epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive
•pulmonary disease (COPD), inflammatory bowel diseases, auto inflammatory
•diseases and rheumatoid arthritis
•- Active cardiovascular disease like congestive heart failure or cardiovascular
•event, such as an acute myocardial infarction or cerebrovascular accident

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