How Effective is the Dose-graded Aerobic Training in Children Survivors of Acute Lymphoblastic Leukemia?
- Conditions
- Acute Lymphoblastic Leukemia
- Interventions
- Other: Traditional physical rehabilitationOther: Dose-graded aerobic exercises
- Registration Number
- NCT05679817
- Lead Sponsor
- Cairo University
- Brief Summary
The purpose of this study was to evaluate the impact of a 12-week dose-graded aerobic exercise program (D-GAE) on cardiopulmonary fitness and physical performance in children survivors of acute lymphoblastic leukemia (ALL). A total of 58 ALL survivors were randomly assigned to the D-GAE group (n = 29, who underwent a combination of traditional physical rehabilitation and intensity- and duration-graded aerobic training three times per week for 12 weeks) or the control group (n = 29, who underwent only traditional physical rehabilitation).
Cardiopulmonary fitness and physical performance were evaluated in both groups before and after treatment.
- Detailed Description
Fifty-eight survivors of ALL were recruited from the hematology-oncology polyclinic at King Khalid Hospital and two referral pediatric hospitals in Riyadh, Saudi Arabia. The study included survivors aged 10-18 years, who completed maintenance therapy, had no abnormalities of the lower limbs or spine and did not participate in a regular exercise program (in the past six months). survivors who had secondary malignancies, significant musculoskeletal/neurological issues affecting the capacity to participate in exercises or neurocognitive impairments were excluded.
Outcome measures
1. Cardiopulmonary fitness: The peak oxygen uptake was assessed through the McMaster cycling protocol.
2. Physical Performance: Three tests were used; the 6-minute walk test, the timed up and down stairs test, and the 4x10 meter Shuttle Run test.
Interventions
The D-GAE group received a 12-week aerobic training, three times in addition to the traditional physical rehabilitation. The D-GAE program commenced with a training intensity corresponding to 50% of the maximum age-predicted heart rate for 25 minutes in the first two weeks, which progressed on a two-week basis, and ended up with a training intensity corresponding to 75% of the maximum age-predicted heart rate for 50 minutes in the last two weeks. The D-GAE program included a warm-up for 5 minutes and a cool-down for 5 minutes. The control group received the traditional physical rehabilitation only, 45 minutes per session, three times a week for 12 consecutive weeks. The program consisted of flexibility exercises, strengthening exercises, balance training, and general conditioning exercises.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 58
- Survivors of childhood ALL
- Age of 10-18 years
- Completion of maintenance therapy
- Free of lower limb or spinal deformities
- Not participating in regular exercise regimens in the past six months
- Secondary malignancies
- Significant musculoskeletal/neurological issues
- Neurocognitive impairments
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control group Traditional physical rehabilitation This group received the traditional physical rehabilitation only D-GAE group Dose-graded aerobic exercises This group received a 12-week aerobic training in addition to the traditional physical rehabilitation.
- Primary Outcome Measures
Name Time Method Peak oxygen uptake 3 months The peak oxygen uptake (mL/kg/min) was assessed through a symptom-free exercise tolerance test (i.e., the McMaster cycling protocol).
- Secondary Outcome Measures
Name Time Method 4x10 meter Shuttle Run test 3 months This test measured the time (seconds) that each child took to run forth and back a 10-meter track. Better performance is indicated by a shorter time.
Six-minute walk test. 3 months This test identified the maximum distance (m) that each child was able to cover over six minutes on a straight flat 30-m walkway, without running or jogging. Walking is regarded as more efficient in line with a longer distance coverage
Timed up and down stairs test 3 months This test measured the time (seconds) that each child took to climb up and down a 14-step stair flight (each 20 cm in height). Better performance is indicated by a shorter time.
Trial Locations
- Locations (1)
Ragab K. Elnaggar
🇸🇦Al Kharj, Riyadh, Saudi Arabia