Impact of a Sleep Debt in Middle-Aged and Older Adults

Not Applicable

Completed

• Conditions: Sleep Restriction
• Interventions: Other: Sleep restriction

• Registration Number: NCT00817700
• Lead Sponsor: University of Chicago

Brief Summary

This project has 6 aims.

1. To examine the impact of recurrent partial sleep loss in young, middle-aged and older men and women. Sleep will be restricted to 4 hours.

2. To test the hypothesis that extending bedtimes to allow for sleep recovery will reverse the metabolic, endocrine, and cardiovascular and neuro-behavioral alterations resulting from sleep restriction. Sleep will be extended to 12 hours following the 4 hour sleep restriction.

3. To test the hypothesis that there are age and gender differences in the total amount of sleep recovery obtained during the week of 12-hour bedtimes.

4. To test the hypothesis that there are age and gender differences in sleep capacity (the amount of time an individual can sleep per night when there is no sleep debt).

5. To test the hypothesis that sleep capacity is partly determined by baseline levels of slow-wave sleep and slow-wave activity.

6. To determine whether sleep capacity is related to sleep need by examining metabolic, endocrine, cardiovascular and neuro-behavioral changes with the amount of the individual sleep debt.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-04
• Primary Completion: 2007-11
• Study Completion: 2008-05
• Study First Submitted: 2009-01-05
• Study First Submitted QC: 2009-01-05
• Study First Posted: 2009-01-06
• Status Verified: 2017-01
• Last Update Submitted: 2017-01-09
• Last Update Posted: 2017-01-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

• normal weight
• healthy
• age 18-75 old

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Exclusion Criteria

• sleep disorder
• irregular life habits (shift workers, travelers)
• smokers
• on medication
• consumption of > 2 alcohol or caffeinated beverages/day

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Sleep restriction	Sleep restriction	Sleep restriction to 4 hours of sleep per night. Overnight sleep recording, measures of endocrine and metabolic (from blood), cardiovascular (measures of blood pressure and heart rate), performance ( before and after sleep restriction and after sleep recovery.

Primary Outcome Measures

Name	Time	Method
Endocrine, metabolic, cardiovascular changes performance and autonomic nervous system activity before and after sleep restriction and after sleep recovery.	Completion of 23 day study

Trial Locations

Locations (1)

The University of Chicago; 🇺🇸 Chicago, Illinois, United States