Sleep, Circadian Rhythms and Cluster Headache
- Conditions
- Cluster Headache
- Interventions
- Other: PolysomnographyOther: Actigraphy
- Registration Number
- NCT01447641
- Lead Sponsor
- University of Surrey
- Brief Summary
The purpose of this study is to assess both the sleep and circadian (24-hourly biological rhythms) physiology of people with cluster headache. For sufferers with the episodic form of the disorder this will involve observation at two separate time points, once when experiencing attacks (in-bout) and once when attack free (out-of-bout).
The study will include measurement of basic rest-activity patterns, sleep timing and timing of individual attacks, as well as a more detailed study recording sleep and circadian rhythms under clinical conditions over consecutive nights.
Studying the differences in these processes in single individuals when they are both experiencing and free from attacks might provide insight into the brain mechanisms involved in triggering the bouts of attacks and individual attacks themselves. An improved understanding of this area may help design improved treatment options in future.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 8
- Diagnosis of cluster headache or closely related primary headache disorder
- Abnormality on screening investigations that increase risk of participation
- Alcohol consumption exceeding 21 units per week
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Cluster headache Polysomnography Cluster headache sufferers (both chronic and episodic) Cluster headache Actigraphy Cluster headache sufferers (both chronic and episodic)
- Primary Outcome Measures
Name Time Method amplitude and phase of circadian rhythm of melatonin 36 hours
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Surrey Clinical Research Centre, University of Surrey
🇬🇧Guildford, United Kingdom