Comparison of invasive measurement of craniospinal compliance with the noninvasively derived surrogate parameter from head electrical capacitance
Recruiting
- Conditions
- Normal-pressure hydrocephalusG91.2
- Registration Number
- DRKS00032337
- Lead Sponsor
- Klinik für Neurochirurgie - Uniklinik Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 52
Inclusion Criteria
Suspected diagnosis of a cerebrospinal fluid circulation disorder
Age > 18 years
Presence of imaging of the neurocranium
Clinical indication for the performance of a CSF infusion test
Written consent
Exclusion Criteria
Intracranial tumour/malformation or tumour/malformation on the head (with the exception of malformations associated with the CSF circulation disorders mentioned above).
- Contraindication to a lumbar infusion test
- Non-removable external foreign bodies or large tattoos on head and neck
- Pregnancy or breastfeeding
- Patch allergy
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method craniospinal compliance resp. <br>Electrical capacity of the head <br>Non-invasively measured blood pressure <br>Respiratory and cardiac activity
- Secondary Outcome Measures
Name Time Method Diagnosed aetiology of hydrocephalus, clinical parameters of gait disturbances, spatial impairment, cognitive abilities, urinary incontinence, pain caused by headaches, visual acuity, parameters of the computerised lumbar infusion test (baseline CSF pressure, pressure-volume index, pulse amplitude), documented intracranial pressures, cell count and total protein in the CSF, diameter of the sonographic optic nerve sheath (ONSD), radiological findings. <br>The following additional variables will be collected: <br>Age and gender of the study participants, BMI, height, presence of comorbidities using the Charlson Comorbidity Index (CCI). <br>previous cranial operations, presence of cranial implants.