The efficacy of lifestyle changes based on the principles of yoga in the management of bronchial asthma
- Conditions
- RespiratoryAsthmaBronchial asthma
- Registration Number
- ISRCTN00815962
- Lead Sponsor
- Central Council for Research in Yoga & Naturopathy (CCRYN) (India)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
The potential subjects (adults of either sex) went through a step-wise screening procedure which consisted of satisfying the following criteria:
1. Clinical history of episodic airway obstruction
2. Forced expiratory volume of one second (FEV1), or peak expiratory flow rate (PEFR) less than 80 percent of predicted normal and more than 10% or at least 200 mL increase in FEV1 15 minutes after administration of two puffs of salbutamol
3. Presence of at least two clinical criteria of mild or moderate bronchial asthma for at least 6 months
1. Any respiratory tract infection during the past 4 weeks
2. On systemic or oral corticosteroid therapy
3. Smokers (any one who had smoked during the last one year was considered a smoker)
4. Concomitant major illness such as coronary heart disease, renal disease or diabetes
5. Practiced yoga or any other similar discipline during 6 months preceding the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Spirometric indices of pulmonary function<br>2. Eosinophilic cationic protein as a marker of the course of the disease<br>3. The degree of exercise-induced bronchoconstriction as percentage of fall in FEV1 with exercise challenge<br>4. Urinary concentration of the prostaglandin D2 metabolite, 11 beta-Prostaglandin F2a (11 beta-PGF2a), before and after the exercise challenge as a marker of mast cell activation<br><br>Recorded at regular intervals at 0 weeks, 2 weeks, 4 weeks and 8 weeks.
- Secondary Outcome Measures
Name Time Method 1. Asthma quality of life: quality of life was measured by using a self-administered Asthma Quality of Life Questionnaire (AQLQ) which is available in bilingual form, i.e. English and Hindi (local Indian language)<br>2. Frequency of rescue medication<br><br>Recorded at regular intervals at 0 weeks, 2 weeks, 4 weeks and 8 weeks.