Impact of Integrating an Addiction Team on Post Liver Transplantation Survival for Alcohol-related Liver Disease and Its Complications: a Multicenter Retrospective Comparative Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 616
- 试验地点
- 1
- 主要终点
- Overall survival of patients transplanted for alcoholic liver disease.
研究概览
简要总结
Investigator seeks to determine wether integrating an addiction team into a liver transplantation unit improves the prognosis of patients with alcohol-related liver disease requiring liver transplantation. Our hypothesis is that patients managed by an addiction team before and after liver transplantation have less frequent alcohol relapses, thus decreasing the risk of cardiovascular complications, de novo cancer, recurrence of alcohol-related cirrhosis, and consequently increasing their overall survival.
详细描述
In this observational, retrospective and multicentre study, investigator seek to determine the effect of integrating an addiction team into liver transplantation unit on prognosis of patients with alcohol-related liver disease requiring liver transplantation. Investigatore plan to compare patients in 2 groups, depending on whether they have received or not specific addiction care before and after transplantation. This study was conducted over a period of 15 years in three French liver transplant units.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Overall survival of patients transplanted for alcoholic liver disease.
时间窗: Date of last news (at least 5 years for surviving patients)
Patient time (delay between date of transplantation and date of last news) + state (alive or deceased)
次要结局
- Alcohol relapse rate(Date of last news (at least 5 years for surviving))
- Severe alcohol relapse rate(Date of last news (at least 5 years for surviving))
- Rate of alcohol-related cirrhosis recurrence(Date of last news (at least 5 years for surviving))
- Rate of development of cardiovascular risk factors(Date of last news (at least 5 years for surviving))
- Cardiovascular event rate(Date of last news (at least 5 years for surviving))
- De novo cancer-free survival(Date of last news (at least 5 years for surviving))