Impact of Integrating an Addiction Team on Post Liver Transplantation Survival for Alcohol-related Liver Disease and Its Complications.
- Conditions
- AlcoholismAlcohol; LiverAlcohol Use Disorder
- Interventions
- Procedure: Liver transplantation
- Registration Number
- NCT04964687
- Lead Sponsor
- University Hospital, Montpellier
- Brief Summary
Investigator seeks to determine wether integrating an addiction team into a liver transplantation unit improves the prognosis of patients with alcohol-related liver disease requiring liver transplantation. Our hypothesis is that patients managed by an addiction team before and after liver transplantation have less frequent alcohol relapses, thus decreasing the risk of cardiovascular complications, de novo cancer, recurrence of alcohol-related cirrhosis, and consequently increasing their overall survival.
- Detailed Description
In this observational, retrospective and multicentre study, investigator seek to determine the effect of integrating an addiction team into liver transplantation unit on prognosis of patients with alcohol-related liver disease requiring liver transplantation. Investigatore plan to compare patients in 2 groups, depending on whether they have received or not specific addiction care before and after transplantation. This study was conducted over a period of 15 years in three French liver transplant units.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 616
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Transplanted patients seen by an addictionology team Liver transplantation Adult patients with alcohol-related liver disease, possibly complicated by hepatocellular carcinoma, that required liver transplantation in participating centers from January 2000 to December 2015, and seen by an addictology team before and after the transplantation. Transplanted patients not seen by an addictionology team Liver transplantation Adult patients with alcohol-related liver disease, possibly complicated by hepatocellular carcinoma, that required liver transplantation in participating centers from January 2000 to December 2015, and seen by an addictology team before and after the transplantation.
- Primary Outcome Measures
Name Time Method Overall survival of patients transplanted for alcoholic liver disease. Date of last news (at least 5 years for surviving patients) Patient time (delay between date of transplantation and date of last news) + state (alive or deceased)
- Secondary Outcome Measures
Name Time Method Alcohol relapse rate Date of last news (at least 5 years for surviving) Number of patients with alcohol relapse among all transplanted patients.
Severe alcohol relapse rate Date of last news (at least 5 years for surviving) Number of patients with severe alcohol relapse among all transplanted patients
Rate of alcohol-related cirrhosis recurrence Date of last news (at least 5 years for surviving) Number of patients with alcohol-related cirrhosis among all transplanted patients.
Rate of development of cardiovascular risk factors Date of last news (at least 5 years for surviving) Number of patients developing one or more cardiovascular risk factors (hypertension, dyslipidemia, diabetes, smoking) among all transplanted patients.
Cardiovascular event rate Date of last news (at least 5 years for surviving) Number of patients with one or more cardiovascular events (coronary syndrome, stroke, arterial disease) among all transplant patients.
De novo cancer-free survival Date of last news (at least 5 years for surviving) Number of patients developing de novo cancer as a function of time among all transplanted patients
Trial Locations
- Locations (1)
Uhmontpellier
🇫🇷Montpellier, France