Assessment of the Effects of Non-calorie Sweeteners on Gut Barrier and Inflammatory Markers Compared to Those of Sugars in Healthy Individuals
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Vienna
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Changes in inflammatory markers.
Study Overview
Brief Summary
The aim of the present study is to determine the effect of non-nutritive sweeteners on intestinal barrier function and inflammatory markers in healthy subjects in comparison to mono- and disaccharides.
Detailed Description
In the intervention study normal weight participants will receive beverages sweetened with non-nutritive sweeteners, mono- and disaccharides for a defined number of days. Before and after intervention parameters of intestinal barrier function will be assessed.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •No known history of metabolic diseases/disorders
- •BMI <25 kg/m2
Exclusion Criteria
- •Food allergies or intolerances (esp. fructose intolerance and malabsorption)
- •Chronic disease of the gastrointestinal tract
- •Renal insufficiency
- •Taking drugs affecting lipid or glucose metabolism
Arms & Interventions
Experimental: Beverage 1
Participants receive a beverage with a defined amount of non-nutritive sweetener.
Intervention: Dietary intervention 1 (Other)
Experimental: Beverage 2
Participants receive a beverage with a defined amount of non-nutritive sweetener.
Intervention: Dietary Intervention 2 (Other)
Experimental: Beverage 3
Participants receive a beverage with a defined amount of monosaccharide.
Intervention: Dietary Intervention 3 (Other)
Experimental: Beverage 4
Participants receive a beverage with a defined amount of disaccharide.
Intervention: Dietary Intervention 4 (Other)
Outcomes
Primary Outcomes
Changes in inflammatory markers.
Time Frame: 1 week
Changes in IL-6 plasma levels (ng/ml).
Changes in parameters of intestinal barrier function.
Time Frame: 1 week
Changes in plasma endotoxin levels.
Secondary Outcomes
- Changes in markers for glucose metabolism.(1 week)
- Changes in blood lipid levels.(1 week)
- Changes in blood pressure.(1 week)
Investigators
Prof. Dr. Ina Bergheim
Principal Investigator
University of Vienna