The effect of non-caloric sweeteners compared with sucrose on the gut microbiome, cardiovascular risk factors, and sex hormones in women with obesity

Swiss National Science Foundation0 个研究点目标入组 160 人开始时间: 待定最近更新: 2021年4月26日

适应症

试验速览

暂无简介。

•Women between 42 and 52 years old
•BMI = 30 kg/m2
•Stable weight (weight change =3 kg in the past 3 months)
•Presence of an intact uterus and at least one ovary
•Report of a menstrual cycle in the three months before screening
•Absence of pregnancy, lactation, or use of oral contraceptives or hormone therapy
•Willing to participate in the study.

•History or diagnosis of thyroid disease (unless controlled by medication), type 1 or 2 diabetes mellitus, kidney disease, liver disease, cardiovascular disease, and chronic gastrointestinal disease
•History of recent infection and antibiotic use
•Consuming alcoholic drinks
•Taking medications that may affect body weight and composition, lipid profile and blood glucose control (including metformin, glibenclamide, atorvastatin, aspirin or other non-steroidal anti-inflammatory drugs), cholestyramine, colestipol, niacin, clofibrate, gemfibrozil, probucol, or 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase inhibitors,
•Being on a specific diet

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