A comparison of repetitive transcranial magnetic stimulation protocols in healthy volunteers for use in neurological disorders.

Not Applicable

Completed

• Conditions: eurological conditions, especially stroke; Neurological conditions, especially stroke; Stroke - Ischaemic

• Registration Number: ACTRN12609000393257
• Lead Sponsor: Graeme Hammond-Tooke

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-06-01
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

Healthy volunteers

Exclusion Criteria

Neurological disease
Epilepsy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Simple motor reaction times; based on pressing a key on a computer keyboard in response to a visual stimulus (green circle), using ePrime software.[Immediately after rTMS, 30 minutes post TMS];Motor evoked potential amplitude using Magstim Rapid2 stimulator at 110% RMT and recording with surface electrodes over the left first dorsal interosseus muscle.[Immediately following rTMS];Cortical silent period, measured as for motor evoked potential amplitude, with participant contracting the first dorsal interosseus at 15% of peak voluntary contraction.[Immediately following rTMS]

Secondary Outcome Measures

Name	Time	Method
Strength: peak contraction as recorded on handgrip and pinchgrip manometers[Immediately after rTMS, 30 minutes post rTMS]