NL-OMON53449
Recruiting
Not Applicable
Integration of Whole-Genome Sequencing profiles and Immune Status in cancer - a molecular profiling protocol to broaden the view on drug targets and immune contexture in patients with melanoma and pancreatic cancer - SONATA
Amsterdam UMC0 sites180 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- maligne neoplasmata pancreas
- Sponsor
- Amsterdam UMC
- Enrollment
- 180
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Diagnosis of locally advanced or metastatic cutaneous/mucosal melanoma or
- •pancreatic cancer, meeting the following characteristics:
- •a. Melanoma
- •i. Patients with histologically proven locally advanced or metastatic melanoma
- •(stage IV), with intrinsic or acquired resistance to treatment with immune
- •checkpoint inhibition (anti\-PD1 antibody \+/\- ipilimumab)
- •ii. Patients with locoregional or distant recurrence either during, or within 3
- •months after completion or discontinuation of (neo)adjuvant anti\-PD1\-based
- •immunotherapy for stage III melanoma.
- •b. Pancreatic cancer
Exclusion Criteria
- •Patients with metastatic or locally advanced lesions which are not considered
- •to be technically and/or safely biopsied
Outcomes
Primary Outcomes
Not specified
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