NL-OMON53449招募中不适用
Integration of Whole-Genome Sequencing profiles and Immune Status in cancer - a molecular profiling protocol to broaden the view on drug targets and immune contexture in patients with melanoma and pancreatic cancer - SONATA
Amsterdam UMC0 个研究点目标入组 180 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 180
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •1. Diagnosis of locally advanced or metastatic cutaneous/mucosal melanoma or
- •pancreatic cancer, meeting the following characteristics:
- •a. Melanoma
- •i. Patients with histologically proven locally advanced or metastatic melanoma
- •(stage IV), with intrinsic or acquired resistance to treatment with immune
- •checkpoint inhibition (anti-PD1 antibody +/- ipilimumab)
- •ii. Patients with locoregional or distant recurrence either during, or within 3
- •months after completion or discontinuation of (neo)adjuvant anti-PD1-based
- •immunotherapy for stage III melanoma.
- •b. Pancreatic cancer
- •i. Patients with histologically proven metastatic pancreatic cancer with
- •progression under or after standard first-line chemotherapy (FOLFIRINOX or
- •gemcitabine/nab-paclitaxel).
- •2. Patients must be willing and able to provide written informed consent and be
- •willing and able to comply with the study protocol.
- •3. Patients must be >=18 years of age.
- •4. Metastatic or locoregional lesion of which a tumour needle biopsy can be
- •safely obtained according to routine clinical practice.
排除标准
- •Patients with metastatic or locally advanced lesions which are not considered
- •to be technically and/or safely biopsied
研究者
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