Biomarker Validation and Whole genome sequencing for Medications-related Osteonecrosis of the Jaw (MRONJ) through Korean MRONJ cohort setup
- Conditions
- Diseases of the digestive system
- Registration Number
- KCT0008077
- Lead Sponsor
- Ewha Womens University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 360
? Adult patients whose age is over 20 years of age and whose jaw growth has been completed
? If you have or have been given a medication that can cause jaw necrosis:IV Bisphosphonate, Denosumab, Angiogenesis inhibitor, etc.Oral use for more than 2 years
? Patients who are scheduled to perform an action that increases the risk of jaw necrosis or have a risk factor
(Oral surgery such as extraction, implant, and denture that does not fit well, periodontitis, etc.)
? Patients who agreed to participate in the clinical trial and signed the patient consent form
? If there is a history of radiation therapy in the head and neck, including jaw, or a malignant tumor of the jaw area
? Patients taking oral bisphosphonate for 2 years or less
? If the examiner determines that participation in the clinical trial is inadeqyate becayse it may affect other ethical or clinical trial results
? Those who do not understand the purpose of the study and do not agree
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Biomarkers (blood, saliva, tissue or bone samples), risk factors
- Secondary Outcome Measures
Name Time Method Clinical characteristic / Demographic evaluation;Radiation examination