Center for Translational Pediatric Pulmonology *Modelling the bronchial epithelium in children*

Recruiting

• Conditions: asthma; cystic fibrosis; wheeze javascript:saveABR('C'); 10038686; 10024967

• Registration Number: NL-OMON48628
• Lead Sponsor: niversitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

children requiring brochoscopy for clinical indications
bronchoscopy will take place during offica hours

Exclusion Criteria

children with malignancies requiring bronchoscopy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>• To establish a model of the bronchial epithelium by epithelial organoid<br /><br>cultures derived from the bronchial and nasal brush, as well as bronchial and<br /><br>nasal brushes of the pediatric airways. We will validate these models using<br /><br>comparative RNA seq with matched single cell RNA seq of airway wall biopsies.</p><br>