The Gut Microbiota in Conventional and Serrated Precursors of Colorectal Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 540
- 试验地点
- 1
- 主要终点
- Prevalence and relative abundance of selected fecal microbial taxa
研究概览
简要总结
Gut microbiota were assessed in 540 colonoscopy-screened adults by 16S rRNA gene sequencing of stool samples. Investigators compared gut microbiota diversity, overall composition, and normalized taxon abundance among these groups.
详细描述
Colorectal cancer is a heterogeneous disease arising from at least two precursors-the conventional adenoma (CA) and the serrated polyp. A relationship between the human gut microbiota and colorectal cancer has been shown; however, its relationship to the different early precursors of colorectal cancer is understudied. This study tested, for the first time, the relationship of the gut microbiota to specific colorectal polyp types.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Both men and women who have visited a gastroenterologist or surgeon, aged 18 or older will be included in this study.
- •Both men and women residents in the United States, aged 18 or older will be included in this study.
排除标准
- •Women who are pregnant will be excluded from participating in this study
- •Subjects on ongoing antibiotic therapy will be excluded from participating in this study.
结局指标
主要结局
Prevalence and relative abundance of selected fecal microbial taxa
时间窗: 2 Days
Quantitative polymerase chain reaction
次要结局
未报告次要终点