Cannabis Use Disorder Treatment Study

Not Applicable

Completed

• Conditions: Cannabis Use Disorder, Severe; Cannabis Use Disorder, Moderate; Cannabis Use Disorder, Mild
• Interventions: Behavioral: Peer Network Counseling-txt

• Registration Number: NCT04567394
• Lead Sponsor: The University of Tennessee, Knoxville

Brief Summary

The purpose of this study is to test a text-delivered counseling program to stop or reduce cannabis use among young adults (ages 18 to 25).

Detailed Description

After being informed about the study and potential risks, participants will complete online screening assessments. Those who are determined to be eligible via online screening will complete a urine drug screen to confirm eligibility. Once eligibility is confirmed, participants will be randomized either to the intervention group or to the wait-list control group. Those who are randomized to the intervention group will receive the 4-week text intervention via smartphone and complete assessments (including urine drug screens) at baseline, 1 month, 3 months, and 6 months. Those who are randomized to the wait-list control group will only complete the assessments (including urine drug screens) at baseline, 1 month, 3 months, and 6 months. Participants who are initially assigned to the wait-list control group can choose to receive the text intervention once their 6-month participation is complete.

Study Timeline

• Study First Submitted: 2020-09-21
• Study First Submitted QC: 2020-09-21
• Study First Posted: 2020-09-28
• Study Start: 2020-12-07
• Status Verified: 2024-05
• Primary Completion: 2025-01-08
• Study Completion: 2025-01-08
• Last Update Submitted: 2025-03-24
• Last Update Posted: 2025-03-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1077

Inclusion Criteria

1. 18 to 25 years old.
2. use of cannabis three or more days during a typical week.
3. a score of at least eight on the Cannabis Use Disorder Identification Test-Revised
4. a urine specimen positive for cannabis metabolites.
5. a score of at least two on the Mini International Neuropsychiatric Interview: Version 7.0.2 for DSM-V, Substance Use Disorder
6. must live in Tennessee or Colorado

Exclusion Criteria

1. substance abuse treatment during the past three months.
2. lack of access to a text-capable phone.
3. unable or unwilling to commit to six months of follow-up.
4. not fluent in English.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intervention	Peer Network Counseling-txt	Participants randomized to the Intervention group will complete questionnaires at baseline, 1 month, 3 months, and 6 months and will receive 4 weeks of the PNC-txt intervention.

Primary Outcome Measures

Name	Time	Method
Change in Past 30-Day Cannabis Use	Baseline, 1 month, 3 months, 6 months	Past-30-day substance use (cannabis, alcohol, tobacco, other drugs) and consequences are measured using the Alcohol, Smoking and Substance Involvement Screening Test
Change from Baseline in Tetrahydrocannabinol (Delta-9-THC-COOH) levels	Baseline, 1 month, 3 months, 6 months	Urine THC levels (50ng/mL, 100ng/mL, 200ng/mL, 300ng/mL) will provide a biological measure for current cannabis use.

Secondary Outcome Measures

Name	Time	Method
Change in Young Adult Social Network Assessment	Baseline, 1 month, 3 months, 6 months	Participants report information on each their 3 closest friends, representing their egocentric network. Individual friend scores are totaled based on all 8 risky and prosocial items (2-9). Thus, each peer's score has a potential range from -32 to 32, with greater scores indicating a healthier relationship. The total peer network health scores is based on the sum of all 24 risky and prosocial items across all three friends. Assuming three peers per participant, total network quality scores may range from -96 to 96, with lower scores indicating greater network risk and higher scores indicating greater network protection.
Cost Measures	6 months	Cost of intervention implementation will be compared to typical treatment cost for cannabis use disorder
Change in Environmental Risk Assessment	Baseline, 1 month, 3 months, 6 months	Participants will report using the Ecological Momentary Assessment reporting about Craving (0=none-10= intense), Cannabis Use (0=none-10= a lot), Mood (0=very good-10= very depressed), and Stress (0=no stress-10 = very stressed) on a 10 point scale for each item

Trial Locations

Locations (2)

University of Tennessee Knoxvile; 🇺🇸 Knoxville, Tennessee, United States

Colorado State University; 🇺🇸 Fort Collins, Colorado, United States