Importance of studying the changes in an enzyme for the metabolism of drug named azathioprine in dermatology patients
Not Applicable
- Conditions
- Health Condition 1: L989- Disorder of the skin and subcutaneous tissue, unspecified
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Consenting patients who had previously received azathioprine or currently on it attending the dermatology OPD during the study period
Exclusion Criteria
Those who had received blood transfusions in the preceding 90-120 days will be excluded for enzyme activity studies
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To estimate the frequency of variations in TPMT levels <br/ ><br>2.To assess the impact of inherited variations of TPMT allele/levels on adverse effects and clinical response to azathioprine in dermatology. <br/ ><br>Timepoint: at the end of one year <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.To estimate the frequency of TPMT genetic polymorphisms <br/ ><br> 2.To study the correlation between TPMT genetic polymorphisms and enzyme levels <br/ ><br>Timepoint: at the end of one year