Cruciferous Vegetable Intake and Histone Status in Screening Colonoscopy Patients

Completed

• Conditions: Colon Cancer

• Registration Number: NCT01344330
• Lead Sponsor: Texas A&M University

Brief Summary

This research study will assess cruciferous vegetable intake in patients presenting for screening colonoscopy and correlate intake with histone status and histone deacetylace (HDAC) expression in tissue biopsy specimens and peripheral blood mononuclear cells (PBMCs). The investigators will also measure sulforaphane (SFN) metabolites in blood as a biomarker of cruciferous vegetable intake.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-04-27
• Study First Submitted QC: 2011-04-28
• Study First Posted: 2011-04-29
• Study Start: 2012-01
• Primary Completion: 2017-12
• Study Completion: 2017-12
• Status Verified: 2020-12
• Last Update Submitted: 2020-12-16
• Last Update Posted: 2020-12-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 108

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cruciferous vegetable intake correlated with SFN and I3C urinary metabolites	At colonoscopy (day 1)

Secondary Outcome Measures

Name	Time	Method
Cruciferous vegetable intake and p21 expression (qRT-PCR, ChIP in PBMCs)	at colonoscopy
Cruciferous vegetable intake correlated with acetylated histone expression (PBMCs, colon tissue),	at colonoscopy
Cruciferous vegetable intake correlated with HDAC activity (in PBMCs)	at colonoscopy

Trial Locations

Locations (1)

Oregon Health & Science University; 🇺🇸 Portland, Oregon, United States