NCT02294695已完成不适用
Early Procalcitonin Kinetics May Indicate Effectiveness of the Empirical Antibiotic Therapy in Sepsis Within Hours
Domonkos Trásy1 个研究点 分布在 1 个国家目标入组 209 人开始时间: 2012年10月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 209
- 试验地点
- 1
- 主要终点
- Procalcitonin kinetic
研究概览
简要总结
To investigate the value of procalcitonin (PCT) kinetics between 0-8-16-24 hours after starting empirical antibiotic therapy in critically ill patients, to predict appropriate or inappropriate antibiotic treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical signs of infection
- •Suspected or proven acute infection requiring empiric antibiotic therapy as decided by the attending ICU physician
- •Suspected site of infection has to be present and documented
- •Microbiological sample sent for staining
- •Inflammatory markers available at the start of the therapy
排除标准
- •Patients younger than 18 years
- •Who received prophylactic or empiric antibiotic therapy 48 hours before inclusion
- •Whose receiving acute renal replacement therapy in the first 24 hours following antibiotic treatment
- •Following cardiopulmonary resuscitation
- •End stage diseases with a "do not resuscitate" order
- •Immunocompromised patients (human immunodeficiency virus infection, bone marrow transplantation, malignant haematological disorders and chemotherapy)
- •Post cardiac surgery patients
结局指标
主要结局
Procalcitonin kinetic
时间窗: The first six days after starting empiric antibiotic treatment
PCT levers are measured every 8 hours in the first day after starting empiric antibiotic treatment then daily and the changes in percentage are followed form the baseline value measured right before the first exposition of the antibiotic therapy.
次要结局
- Sequential Organ Failure Assessment score(The first six days after starting empiric antibiotic treatment)
研究者
Domonkos Trásy
Ph.D. student; Department of Anaesthesiology and Intensive Therapy
Szeged University
研究点 (1)
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