Early Procalcitonin Kinetics May Indicate Effectiveness of the Empirical Antibiotic Therapy in Sepsis Within Hours

Domonkos Trásy1 site in 1 country209 target enrollmentOctober 2012

ConditionsBacterial Infections

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Bacterial Infections
Sponsor: Domonkos Trásy
Enrollment: 209
Locations: 1
Primary Endpoint: Procalcitonin kinetic
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

To investigate the value of procalcitonin (PCT) kinetics between 0-8-16-24 hours after starting empirical antibiotic therapy in critically ill patients, to predict appropriate or inappropriate antibiotic treatment.

Registry

clinicaltrials.gov

Start Date

October 2012

End Date

October 2013

Last Updated

9 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Domonkos Trásy

Responsible Party

Sponsor Investigator

Principal Investigator

Domonkos Trásy

Ph.D. student; Department of Anaesthesiology and Intensive Therapy

Szeged University

Eligibility Criteria

Inclusion Criteria

•Clinical signs of infection
•Suspected or proven acute infection requiring empiric antibiotic therapy as decided by the attending ICU physician
•Suspected site of infection has to be present and documented
•Microbiological sample sent for staining
•Inflammatory markers available at the start of the therapy

Exclusion Criteria

•Patients younger than 18 years
•Who received prophylactic or empiric antibiotic therapy 48 hours before inclusion
•Whose receiving acute renal replacement therapy in the first 24 hours following antibiotic treatment
•Following cardiopulmonary resuscitation
•End stage diseases with a "do not resuscitate" order
•Immunocompromised patients (human immunodeficiency virus infection, bone marrow transplantation, malignant haematological disorders and chemotherapy)
•Post cardiac surgery patients

Outcomes

Primary Outcomes

Procalcitonin kinetic

Time Frame: The first six days after starting empiric antibiotic treatment

PCT levers are measured every 8 hours in the first day after starting empiric antibiotic treatment then daily and the changes in percentage are followed form the baseline value measured right before the first exposition of the antibiotic therapy.