Increase in Procalcitonin Kinetics May be a Good Indicator of Starting Empirical Antibiotic Treatment in Critically Ill Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 114
- 试验地点
- 1
- 主要终点
- Procalcitonin kinetic
研究概览
简要总结
The value of procalcitonin change from the day before to the day when infection was suspected in predicting bacterial infection in intensive care patients.
详细描述
Starting antibiotic therapy early in critically ill patients with suspected infection is of utmost importance with significant effect on survival. Procalcitonin is a reliable sepsis marker but results about its usefulness in initiating antimicrobials are conflicting. Our aim is to investigate the predictive value of 24 hours procalcitonin kinetics before starting empirical antibiotic therapy in intensive care patients as an indicator of the presence of bacterial infection.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical signs of infection
- •Suspected or proven acute infection requiring empiric antibiotic therapy as decided by the attending ICU physician
- •Microbiological sample sent for staining
- •Inflammatory markers available from the previous day
排除标准
- •Patients younger than 18 years
- •Who received prophylactic or empiric antibiotic therapy 48 hours before inclusion
- •Whose receiving acute renal replacement therapy in the first 24 hours following antibiotic treatment
- •Following cardiopulmonary resuscitation
- •End stage diseases with a "do not resuscitate" order
- •Immunocompromised patients (human immunodeficiency virus infection, bone marrow transplantation, malignant haematological disorders and chemotherapy)
- •Post cardiac surgery patients
结局指标
主要结局
Procalcitonin kinetic
时间窗: 24 hours before starting empiric antibiotic treatment
Procalcitonin levels are measured at starting empiric antibiotic treatment and 24 hours before. The changes in percentage are calculated form the day before and right before the first exposition of the antibiotic therapy.
次要结局
- White blood cell count kinetic(24 hours before starting empiric antibiotic treatment)
- Body temperature kinetic(24 hours before starting empiric antibiotic treatment)
- C-reactive protein kinetic(24 hours before starting empiric antibiotic treatment)
研究者
Domonkos Trásy
Ph.D. student; Department of Anaesthesiology and Intensive Therapy
Szeged University