Children of the UK Pregnancies Better Eating and Activity Trial

Not Applicable

• Conditions: Prevention of early adverse cardiovascular remodelling in children born to obese mothers; Circulatory System

• Registration Number: ISRCTN29498878
• Lead Sponsor: King's College London

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-04-03
• Last Update Posted: 22 May 2023
• Study Completion: 2026-01-30

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 700

Inclusion Criteria

Women who took part in UPBEAT during their pregnancy and their 9-11-year-old children

Exclusion Criteria

1. Inability and unwillingness to provide informed consent
2. Any major health problems which may impact the development of the cardiovascular system or body composition
3. Women and their children who did not take part in the previous UPBEAT study

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
eft ventricular mass measured using transthoracic echocardiography at a single timepoint

Secondary Outcome Measures

Name	Time	Method
Measured at a single timepoint:<br>1. Blood pressure and heart rate variability measured during clinical visits and by ambulatory monitors over 24 hours<br>2. Cardiac structure and function measured using transthoracic echocardiography<br>3. Arterial stiffness measured using pulse-wave velocity<br>4. Carotid intima-media thickness measured using vascular ultrasound<br>5. Body composition analysis measured using dual-energy X-ray absorptiometry (DEXA) and anthropometry<br>6. Cardiorespiratory fitness estimated using a sub-maximal fitness test