NL-OMON23641
Recruiting
Not Applicable
Early detection of cardiac dysfunction in childhood cancer survivors; a DCOG LATER study
Princess Maxima Center for pediatric oncology, Amsterdam UMC (AMC), Radboudumc, SKIO0 sites2,200 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiotoxicity in childhood cancer survivors
- Sponsor
- Princess Maxima Center for pediatric oncology, Amsterdam UMC (AMC), Radboudumc, SKIO
- Enrollment
- 2200
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Eligible survivors are 5\-year childhood cancer survivors (CCS) diagnosed before the age of 18 years, between 1/1/1963 and 12/31/2001 with a malignancy according to the third edition of the International Classification of Childhood Cancer. We only included CCS who were living in the Netherlands at the time of childhood cancer diagnosis and who were treated in one of the Dutch pediatric oncology/hematology centers (Academic Medical Center Amsterdam, VU University Medical Center, Leiden University Medical Center, Erasmus Medical Center, University Medical Center Groningen, Radboudumc, and University Medical Center Utrecht). This study will include 4 risk groups; risk group 1: CCS who have received anthracyclines, mitoxantrone, or irradiation to the heart region; risk group 2 (max n\=100\): cyclophosphamide only (no anthracyclines, mitoxantrone, or irradiation to the heart region, ifosfamide or vincristine); risk group 3 (max n\=100\): ifosfamide only (no anthracyclines, mitoxantrone, or irradiation to the heart region, cyclophosphamide or vincristine); risk group 4 (max n\=100\): vincristine only (no anthracyclines, mitoxantrone, or irradiation to the heart region, ifosfamide or cyclophosphamide), irrespective current age. For the comparison group 500 healthy siblings will be included.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Not specified
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