The HexAs study: Measuring differences in breathing patterns between asthma patients and healthy subjects during physical exercise and the effect on the level of dyspnoea using respiratory inductance plethysmography

Conditions: Asthma

Registration Number: NL-OMON24296

Lead Sponsor: Medisch Spectrum Twente

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 108

Inclusion Criteria

Asthma group:
-Confirmed asthma diagnosis by a health professional
-Patient using ICS on daily basis
-Normal lung function under treatment (FEV1>80% predicted post salbutamol)
-Age 18-60
-Written informed consent prior to participation

Healthy group:
-No pulmonary disease
-No usage of lung related medication
-Age 18-60
-Written informed consent prior to participation

Exclusion Criteria

-Has had an asthma exacerbation within 6 weeks before inclusion (asthma group only)
-More than 10 pack-years
-Pulmonary disease other than asthma
-No neurological or muscular disorder
-Not able to perform cycling ergometry.
-Does not fit one of the available Hexoskin shirts.
-Meets a contra-indication of the cycling ergometry protocol from the pulmonary department at MST (document: K6 protocol for cycling ergometry MST)
-Has been tested positively for COVID-19 in the past 3 months or has not fully recovered from an earlier COVID-19 infection
-Inability to read and/or understand the Dutch language

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The main study parameter is the breathing pattern of the subjects. The breathing pattern will be defined as follows: the breathing pattern describes the extent to which breathing frequency, tidal volume, abdominal breathing, and thoracic breathing contribute to the respiratory minute volume and how these change with different levels of physical exercise.

Secondary Outcome Measures

Name	Time	Method
The secondary study parameters are parameters that might indicate the effects of the different breathing patterns. The level of dyspnoea is determined by the VAS and BORG score. EIB is a possible confounder, therefore, spirometry and FOT are done to investigate whether EIB is a contributor to possibly investigated dyspnoea.<br><br>Other parameters like the ACQ, mini-AQLQ, NQ, fat percentage, smoking status, frequency of physical exercise, medication use and the standard parameters measured during cycling ergometry are used to monitor whether other possible factors exist that affect the breathing pattern.<br>