The efficacy and safety of weissella cibaria CMU on halitosis
- Conditions
- Diseases of th respiratory system
- Registration Number
- KCT0003301
- Lead Sponsor
- Dankook University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
1) Male and female aged 20 to over 70
2) A person with a score of 2 or more in the bad taste sensory evaluation (OLT) and a VSC
concentration (H2S, CH3SH, (CH3) 2S) of 1.5ng or more
3) The person who agrees to participate in this test and who has voluntarily signed the written
agreement (or legal representative)
1) Those who are currently being treated or have a history of systemic disease (liver disease, renal
disease, Sjogren's syndrome, rheumatic disease) that may cause bad breath (however, taking
into consideration the condition of the subject,
2) Persons with severe dental disease (periodontal disease, dental caries, dry mouth) (dental caries in
the dental caries test may be included in the test, except when more than one dental caries)
3) Those with uncontrolled hypertension (160 / 100mmHg or higher, after 5 minutes of test subjects
)
4) diabetic patients taking fasting blood glucose levels greater than 126 mg / dl, randomized blood
glucose levels greater than 200 mg / dl, or taking oral hypoglycemic agents or insulin
5) AST (GOT) or ALT (GPT) blood pressure is three times higher than the normal upper limit of the
institution
6) creatinine whose plasma level is more than twice the upper limit of normal level
7) Those taking antibiotics within 2 weeks before screening
8) Smokers
9) Those who complain of severe gastrointestinal symptoms such as heartburn and indigestion
10) Screening criteria Probiotic health functional foods within one week and those who consume
fermented milk continuously (more than 4 times a week)
11) Those who are pregnant, breastfeeding, or who have a pregnancy plan during the study period
12) Applicable to human body Any person who is sensitive or allergic to food related food
13) Those who intend to participate in other tests during this human body application test.
14) Those who participated in another human body test within 4 weeks
15) A person who is deemed by the tester to be unsuitable for this human body test
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Volatile sulfur compound concentrationby Oralchroma
- Secondary Outcome Measures
Name Time Method Organoleptic halitosis check;tongue plaque;simplified oral hygiene index;simplified oral hygiene index;gingival index