Effects of chemotherapy upon female fertility

Not Applicable

Completed

• Conditions: Topic: National Cancer Research Network, Reproductive Health; Subtopic: All Cancers/Misc Sites; Disease: Miscellaneous; Cancer; Breast cancer

• Registration Number: ISRCTN28988709
• Lead Sponsor: niversity of Warwick (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-12-06
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

1. Women aged 18 - 43 years
2. Newly diagnosed cancer - mainly with breast cancer and lymphoma

Exclusion Criteria

1. A history of previous exposure to gonadotoxic agents and/or radiotherapy
2. Diagnosed with end stage cancer having a very poor prognosis (less than 10% chances of 1 year survival)
3. Significant ovarian pathology or previous bilateral oophrectomy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the impact of different types, doses and duration of chemotherapy on ovarian reserve using AMH, measured at 6, 9, 12 and 60 months

Secondary Outcome Measures

Name	Time	Method
To assess the accuracy of serum AMH testing in predicting future reproductive capacity, measured at 60 months