Effect of High-Intensity Interval Training and Moderate-Intensity Continuous Training on Abdominal Fat Mass and Energy Substrates Utilization in Postmenopausal Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Change from baseline abdominal fat mass (g) after 3 months of training (T3-T0/T0 x 100)
研究概览
简要总结
Postmenopausal women, as men, are more prone to central or android obesity than premenopausal women. Abdominal fat mass accumulation is associated with an increase of cardiovascular disease (CVD) risk.
Most exercise programs designed for weight loss have focused on about 30 min several times per week of moderate intensity continuous training (MICT). Disappointingly, such exercise programs have led to either none or low fat loss. Accumulating evidence suggests that high intensity interval training (HIIT) should be an effective exercise protocol for reducing body fat of overweight individuals, especially at the abdominal level.
Resistance Training (RT) is associated with increased muscle mass and strength gain in main muscles groups. Thus, RT seems to be an interesting strategy to fight against deconditioning and autonomy loss with age. Development of muscle mass enhances resting metabolism rate. Thus, RT could raise daily energy expenditure ie. substrates' oxidation including lipids.
The aim of our study was to compare the effects of a 12-week moderate intensity continuous training (MICT) program with high intensity interval training (HIIT) program combined or not with a resistance training (RT) program on total abdominal and visceral fat mass and substrate utilization in postmenopausal women.
It is hypothesized that HIIT compared to MICT program would result in significantly greater whole body and regional fat mass losses (abdominal and visceral) and would improve lipid oxidation at rest and during prolonged moderate exercise. It is also hypothesized that HIIT associated with RT could be the best strategy to reduce fat mass.
详细描述
Overweight and obesity are dramatically spreading worldwide, and these trends are occurring in both developed and developing countries. Fat mass and more particularly abdominal fat mass is related to the development of cardio-vascular diseases (CVD). Postmenopausal women, as men, are more prone to central or android obesity.
Most exercise programs designed for weight loss have focused on about 30 min several times a week of moderate intensity continuous training (MICT). Disappointingly, such exercise programs have led to either none or low fat losses. Accumulating evidence suggests that high intensity interval training (HIIT) could be an effective exercise protocol for reducing adipose tissue of overweight individuals, especially at the abdominal level. HIIT involves brief high-intensity, anaerobic exercise followed by brief but slightly longer bouts of very low-intensity exercise.
Resistance training (RT) program are currently proposed in order to reduce fat mass / preserve fat-free mass. Their beneficial effects have been demonstrated, especially in the elderly. Through development (or maintenance) of muscle mass, RT increases resting metabolism rate, daily energy expenditure, and substrate (fatty acids) oxidation.
The aim of the study was to compare the effects of a 12-week moderate intensity continuous training (MICT) program with high intensity interval training (HIIT) combined or not with resistance training (RT) program on total, abdominal and visceral fat mass and substrate utilization at rest and during exercise in postmenopausal women.
36 postmenopausal women will be randomly assigned to MICT (n= 12) or HIIT (n= 12) or HIIT + RT (n= 12) group. Subjects performed three sessions per week during 12 weeks, on bicycle.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
盲法说明
Data collected on the volunteers will be made anonymous.
入排标准
- 年龄范围
- 55 Years 至 82 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Postmenopausal women (55- 82 years)
- •BMI ≥ 25 and < 40
- •Able to follow an exercise protocol
- •Eating behavior and physical activity stable since at least 3 month
排除标准
- •Subject not able to perform exercise after medical examination
- •Subject not able to perform bicycle exercise (pains)
- •Chronic infection
- •Use of β-blocker
- •Medical treatment that could interfere with the different outcome measures
- •Hormonal Replacement Therapy (HRT)
- •Regular consumption of alcohol
- •Refusal to sign the consent form
研究组 & 干预措施
High Intensity Interval Training program (HIIT)
Subjects perform three sessions of training during 12 weeks: 35 min at 50% maximal aerobic power on bicycle.
干预措施: Training programs (Other)
Moderate Intensity Continuous Training program (MICT)
Subjects perform three sessions of training during 12 weeks: repeated cycles of sprinting for 8s and pedaling slowly for 12s (between 20 and 30 rpm) for a maximum of 60 repeats per session.
干预措施: Training programs (Other)
HIIT + Resistance Training program (RT)
Subjects perform three sessions of training during 12 weeks: Each subject performed HIIT protocol and then a single set of 8 exercises with 1 ou 2min resting period between exercises. Each set consisted of 8-12 repetitions at about 80% maximum repetition.
干预措施: Training programs (Other)
结局指标
主要结局
Change from baseline abdominal fat mass (g) after 3 months of training (T3-T0/T0 x 100)
时间窗: Baseline T0, 3 months after protocol starting
Total abdominal fat mass will be measured in all patients using DEXA based on the methodology of Martin and Jensen (1991; L1-L2 to pubic rami) before (baseline, T0) and after 3 months of training (T3).
次要结局
- Plasma HbA1c(Baseline T0, 3 months after protocol starting)
- Glucose level(Baseline T0, 3 months after protocol starting)
- Visceral fat mass(Baseline T0, 3 months after protocol starting)
- Plasma HDL-cholesterol(Baseline T0, 3 months after protocol starting)
- Lipids oxidation evaluated by gas exchange measurements(1 week, 3 months after protocol starting)
- Total fat mass(Baseline T0, 3 months after protocol starting)
- Fat-free mass(Baseline T0, 3 months after protocol starting)
- Plasma triglycerides(Baseline T0, 3 months after protocol starting)
- Plasma total cholesterol(Baseline T0, 3 months after protocol starting)
- Insulin level(Baseline T0, 3 months after protocol starting)
- Plasma LDL-cholesterol(Baseline T0, 3 months after protocol starting)