Inflammatory and Metabolic Outcomes After Obese Woman Performed High Intensity Interval Training

Not Applicable

Completed

• Conditions: Obesity and Metabolic Syndrome
• Interventions: Other: CTR; Other: MICT; Other: HIIT

• Registration Number: NCT03409172
• Lead Sponsor: University of Sao Paulo

Brief Summary

The main purpose of this study is to compare the effects of high intensity interval training and moderate intensity continuous training on inflammatory profile and metabolic markers, after 8 weeks of intervention trial in obese women.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Study Start: 2016-06-01
• Status Verified: 2018-01
• Primary Completion: 2018-01-08
• Study Completion: 2018-01-08
• Study First Submitted: 2018-01-09
• Study First Submitted QC: 2018-01-23
• Last Update Submitted: 2018-01-23
• Study First Posted: 2018-01-24
• Last Update Posted: 2018-01-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 48

Inclusion Criteria

• Body Mass Index between (30-40 kg/m²)
• age between 25 and 41 years
• to be sedentary

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Exclusion Criteria

• type 1 or type 2 diabetes
• Hypertension
• pregnancy, Lactation
• having undergone bariatric surgery
• psychological disorders, epilepsy, sever neurological disorders
• participation in other moderate, vigorous exercise or nutrition intervention
• acute or chronic cardiovascular disease
• malignant disease
• kidney disease
• lung disease
• hyperthyroidism or hypothyroidism
• smoking any type of cigarette
• joint limitations
• electronic implants (defibrillator, pacemaker)

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group (CTr)	CTR	No counseling or nutritional therapy and no exercise
Moderate intensity continuous training (MICT)	MICT	Follow-up during a period of 8 weeks of supervised ergometer-based moderate-intensity continuous training based on HRmax (MICT). MICT: * 3 sessions per week * intensity at 65-75% HRmax * time-effort per session: 50 min
High Intensity Interval Training (HIIT)	HIIT	Procedures: Follow-up during a period of 8 weeks of supervised ergometer-based high intensity interval training based on HRmax (HIIT). HIIT: * 3 sessions per week * 10 bouts of one minute at 90% HRmax interspersed by one minute at 40% HRmax * time-effort per session: 25 min

Primary Outcome Measures

Name	Time	Method
Inflammatory profile	8 weeks (baseline to 8 week follow-up assessment)	Interleukin 10 (IL-10) pg/mL, Interleukin-1B (IL-1B) pg/mL, Tumor Necrosis Factor (TNF)-α (pg/mL), Adiponectin (pg/mL), Monocyte chemoattractant protein 1 (MCP-1) (pg/mL), Leptin (pg/mL)

Secondary Outcome Measures

Name	Time	Method
Body Composition and Anthropometric profile	8 weeks (baseline to 8 week follow-up assessment) ]	Body Adiposity Index (BAI) and Waist-To-Hip Ratio (WHR)
Cardiorespiratory Fitness (CRF)	8 weeks (baseline to 8 week follow-up assessment) ]	CRF was assessed by measuring Peak Oxygen uptake (VO2peak) mL/kg/min
Lipid profile	8 weeks (baseline to 8 week follow-up assessment) ]	Lipid profile was assessed by measuring levels of triglyceride (TG) (mg/dL), total cholesterol (CT) (mg/dL), high-density lipoprotein cholesterol (HDL-C) (mg/dL) and low-density lipoprotein cholesterol (LDL-C) (mg/dL)
Blood Pressure (BP)	8 weeks (baseline to 8 week follow-up assessment) ]	Blood Pressure (mmHg) was assessed by measuring rest levels of Systolic blood pressure (SBP) and Diastolic blood pressure (DBP)
Insulin sensitivity	8 weeks (baseline to 8 week follow-up assessment) ]	Insulin sensitivity was estimated using homeostasis model assessment index (HOMA)
Resting Energy Expenditure (REE)	8 weeks (baseline to 8 week follow-up assessment) ]	Resting Energy Expenditure (kcal/day) was measured through indirect calorimetry with an open-circuit ventilated-hood system Substrate oxidation rate was calculated from VO2 (mL/min) and VCO2 (mL/min)
Substrate oxidation rate	8 weeks (baseline to 8 week follow-up assessment) ]	Substrate oxidation rate was calculated from VO2 (mL/min) and VCO2 (mL/min)