Inflammatory and Metabolic Outcomes After Obese Woman Performed High Intensity Interval Training
- Conditions
- Obesity and Metabolic Syndrome
- Registration Number
- NCT03409172
- Lead Sponsor
- University of Sao Paulo
- Brief Summary
The main purpose of this study is to compare the effects of high intensity interval training and moderate intensity continuous training on inflammatory profile and metabolic markers, after 8 weeks of intervention trial in obese women.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 48
- Body Mass Index between (30-40 kg/m²)
- age between 25 and 41 years
- to be sedentary
- type 1 or type 2 diabetes
- Hypertension
- pregnancy, Lactation
- having undergone bariatric surgery
- psychological disorders, epilepsy, sever neurological disorders
- participation in other moderate, vigorous exercise or nutrition intervention
- acute or chronic cardiovascular disease
- malignant disease
- kidney disease
- lung disease
- hyperthyroidism or hypothyroidism
- smoking any type of cigarette
- joint limitations
- electronic implants (defibrillator, pacemaker)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Inflammatory profile 8 weeks (baseline to 8 week follow-up assessment) Interleukin 10 (IL-10) pg/mL, Interleukin-1B (IL-1B) pg/mL, Tumor Necrosis Factor (TNF)-α (pg/mL), Adiponectin (pg/mL), Monocyte chemoattractant protein 1 (MCP-1) (pg/mL), Leptin (pg/mL)
- Secondary Outcome Measures
Name Time Method Substrate oxidation rate 8 weeks (baseline to 8 week follow-up assessment) ] Substrate oxidation rate was calculated from VO2 (mL/min) and VCO2 (mL/min)
Body Composition and Anthropometric profile 8 weeks (baseline to 8 week follow-up assessment) ] Body Adiposity Index (BAI) and Waist-To-Hip Ratio (WHR)
Cardiorespiratory Fitness (CRF) 8 weeks (baseline to 8 week follow-up assessment) ] CRF was assessed by measuring Peak Oxygen uptake (VO2peak) mL/kg/min
Lipid profile 8 weeks (baseline to 8 week follow-up assessment) ] Lipid profile was assessed by measuring levels of triglyceride (TG) (mg/dL), total cholesterol (CT) (mg/dL), high-density lipoprotein cholesterol (HDL-C) (mg/dL) and low-density lipoprotein cholesterol (LDL-C) (mg/dL)
Blood Pressure (BP) 8 weeks (baseline to 8 week follow-up assessment) ] Blood Pressure (mmHg) was assessed by measuring rest levels of Systolic blood pressure (SBP) and Diastolic blood pressure (DBP)
Insulin sensitivity 8 weeks (baseline to 8 week follow-up assessment) ] Insulin sensitivity was estimated using homeostasis model assessment index (HOMA)
Resting Energy Expenditure (REE) 8 weeks (baseline to 8 week follow-up assessment) ] Resting Energy Expenditure (kcal/day) was measured through indirect calorimetry with an open-circuit ventilated-hood system Substrate oxidation rate was calculated from VO2 (mL/min) and VCO2 (mL/min)