Effectivenes of nebulized Dexmedetomidine for treatment of post dural puncture headache undergoing elective surgeries under spinal anaesthesia: a randomized controlled study

•Informed written consent will be taken from all patients. Basic details will be recorded. Baseline hemodynamic parameters will be noted. •PDPH was diagnosed by the four criteria of the International Classification of Headache Disorders (ICH-II) guidelines which include a postural headache develops within 5 days after lumbar puncture, worsens within 15 min of sitting or standing and improves within 15 min after lying down, associated with at least one of the following: neck stiffness, nausea, photophobia, and tinnitus, and resolves either spontaneously within 1 week or within 48 h after effective treatment of the CSF leak. •Patients who underwent spinal anaesthesia and developed PDPH, will be divided into 2 groups. •GROUP 1: DEXMEDETOMIDINE GROUP - received nebulisation with dexmedetomidine 1micro grams/kg diluted in 4ml 0.9% saline twice daily starting from the PDPH diagnosis and for 3 days. •GROUP 2: CONTROL GROUP - received nebulisation with 4ml 0-9% saline twice daily starting from PDPH diagnosis and for 3 days. •Both groups received conservative management, which consist of bed rest in supine position, good hydration of 30ml/kg/day, paracetamol 1gm IV Q6H, oral caffeine 200mg Q6H, Diclofenac 75mg in 100ml NS infusion SOS.