JPRN-jRCT1030230084
招募中
未知
A Study on the Pathophysiological Mechanisms of Reduced Pain Thresholds in Parkinson's Disease with Thermal-Induced Painful Stimuli
Abe Mitsunari0 个研究点目标入组 90 人2023年5月21日
概览
- 阶段
- 未知
- 干预措施
- 未指定
- 疾病 / 适应症
- healthy subjectsParkinson Disease
- 发起方
- Abe Mitsunari
- 入组人数
- 90
- 状态
- 招募中
- 最后更新
- 2年前
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •Parkinson's Disease Arm
- •1\. Meet the diagnostic criteria of clinically established Parkinson's disease or clinically probable Parkinson disease according to the International Parkinson and Movement Disorder Society diagnostic criteria.
- •2\. Have a Hoehn \& Yahr stage of 3 or less.
- •3\. 50 years of age or older.
- •Healthy Elderly Control Arm
- •1\. 50 years of age or older.
- •2\. Do not meet the above criteria for Parkinson's disease.
- •Healthy Young Control
- •1\. 20 years of age or older but less than 50 years.
- •2\. Do not meet the above criteria for Parkinson's disease.
排除标准
- •1\. Diagnosis of diseases that cause specific chronic pain, such as osteoarthritis, rheumatoid arthritis, irritable bowel syndrome, fibromyalgia, complex regional pain syndrome, multiple sclerosis, and others.
- •2\. Presence of chronic pain.
- •3\. Presence of pain on the day of the visit.
- •4\. History of major depression or bipolar disorder as defined by DSM\-IV within the past year, or a history of schizophrenia as defined by DSM\-IV in the past.
- •5\. Presence of parkinsonism.
- •6\. Presence of skin lesions, such as burns, on the non\-dominant forearm to be stimulated with thermal stimuli.
- •7\. History of alcohol or drug dependency defined by DSM\-IV within the past two years.
- •8\. Presence of significant psychiatric symptoms, excitability, or behavioral abnormalities that would make it difficult to comply with the protocol within the past three months.
- •9\. Presence of systemic severe deseases or unstable conditions.
- •10\. Presence of other abnormalities that affect cognitive function, such as infections or metabolic disorders.
结局指标
主要结局
未指定
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