Elucidation of the pathophysiological mechanism of dementia and clinical research for creation of drug discovery targets - Elucidation of the pathophysiological mechanism of dementia

Keio University, School of Medicine0 sites500 target enrollmentMarch 31, 2018

Overview

Phase: 未知
Intervention: Not specified
Conditions: Not specified
Sponsor: Keio University, School of Medicine
Enrollment: 500
Status: Recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

No summary available.

Registry

who.int

Start Date

March 31, 2018

End Date

March 31, 2026

Last Updated

2 years ago

Study Type

Interventional

Sex

All

Investigators

Sponsor

Keio University, School of Medicine

Eligibility Criteria

Inclusion Criteria

Not provided

Exclusion Criteria

•1\. When a cerebral infarction or a local lesion which affects infection or cognitive function is found by MRI at screening. Small infarcts in the deep area and diffuse changes in the white matter allow incorporation except those occurring in specific sites affecting cognitive function, but in principle cortical infarction is excluded. 2\. There is a problem to take a MRI imaging due to pacemaker, aneurysm clip, artificial valve, cochlear implant or other magnetic or electrically conductive metal, or claustrophobia. 3\. If you have psychiatric symptoms, excitability, behavior abnormalities that make it difficult to follow the protocol within the past 3 months. 4\. When suffering from severe systemic disease or unstable disease. 5\. There are abnormalities affecting cognitive function in vitamin B 12 deficiency, syphilis, thyroid function. 6\. When performing lumbar puncture, if you are taking antiplatelet medications, take the following drug withdrawal period into consideration before the examination. 7\. Subject is participating in any treatment drug trials. 8\. It is clear that participation in clinical trials of Alzheimer's disease treatment drug is made during the 3\-year research period. 9\. When taking a combination prohibited medicine such as warfarin. 10\. Huntington's disease, multiple cerebral infarction, normal pressure hydrocephalus, brain tumor, epilepsy, paroxysmal disease, subdural hematoma, multiple sclerosis. 11\. When there is a history of juvenile onset normal schizophrenia. 12\. It is judged by the attending physician not to be appropriate.