Does ATP cause Annexin A5 targeting in the human forearm?

• Conditions: bloodvessel calcification; atherosclerosis; 10003216

• Registration Number: NL-OMON31848
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 51

Inclusion Criteria

-Male
-Age 18-50 years
-Informed consent

Exclusion Criteria

-History of any cardiovascular disease
-Hypertension (in supine position: systole > 140 mmHg, diastole > 90 mmHg)
-Diabetes mellitus (fasting glucose > 7.0 mmol/L or random glucose > 11.0 mmol/L)
-Hyperlipidaemia (fasting total cholesterol > 5.5 mmol/l or random cholesterol > 6.5mmol/L)
-Drug abuse
-Concomitant chronic use of medication
-Administration of radioactivity for research purposes with an effective dose over 5mSV, during the last 5 years
-Participation to any drug-investigation during the previous 60 days as checked with VIP check according to CRCN standard procedures

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Percentage difference in radioactivity (counts/pixel) between experimental and<br /><br>control thenar muscle at 60 and 240 minutes after Anneinx administration</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To study influence of adenosine infusion and ischemic preconditioning on ATP<br /><br>induced Annexin A5 targeting.</p><br>