Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 294
- 试验地点
- 4
- 主要终点
- Correlation between Pavlovian conditioned approach (PavCA) bias score (out-of-scanner) and composite cannabis use score
研究概览
简要总结
This study seeks to understand individual differences in personality, brain function, and behavior.
Study hypothesis:
- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 22 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-22 years old at baseline
- •Right-handed
- •Medically/physically able to give informed consent
- •English-speaking
- •Substance use is free to vary, but for participants with a history of substance use, ≥ 1 use of cannabis (including less than a full dose)
排除标准
- •Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine)
- •History of psychosis in self or first-degree relative
- •Current treatment for substance use disorder
- •Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication)
- •Intelligence quotient (IQ) < 70
- •Lifetime history of head trauma with loss of consciousness > 5 minutes
- •Reliance on glasses to be able to read small text at a distance of approximately 30 inches
- •Colorblindness
- •MRI contraindication (e.g., pregnancy, metal implants, claustrophobia) per protocol
研究组 & 干预措施
Assessment group
干预措施: Questionnaires and surveys (Behavioral)
Assessment group
干预措施: fMRI (Device)
Assessment group
干预措施: Behavioral tasks and eye tracking (Behavioral)
结局指标
主要结局
Correlation between Pavlovian conditioned approach (PavCA) bias score (out-of-scanner) and composite cannabis use score
时间窗: Baseline
PavCA bias score based on eye gaze during the Pavlovian conditioned approach task will be correlated with a cannabis use composite score based on the Substance Use History and Timeline Follow-Back.
次要结局
- Correlation between PavCA bias score (out-of-scanner) and activation from the Cannabis Cue Reactivity Task (P-CAN)(Baseline)
研究者
Lora Cope
Assistant Professor Psychiatry
University of Michigan