Screening Evaluation for Studies of Chronic Obstructive Pulmonary Disease (COPD)

Completed

Brief Summary: This research is being done to study mechanisms of progression of COPD and to develop treatments for it. The investigators are doing the present study to identify people age 40 and older with mild to moderate COPD who will qualify for such studies to include in a database. The study will include establishing a screening evaluation or characterization of the following two studies:

* Emphysema Progression in COPD- Losartan's Effects on Airway Parameters - NA_00009980

* Sleep-Related Physiology and Inflammation in Chronic Obstructive Pulmonary Disease - NA_00001771

Detailed Description: This is a program to recruit and screen participants for clinical trials or more detailed observational studies of COPD. There are no interventions or comparative results to be published from this study.

Recruitment & Eligibility

Inclusion Criteria

Age 40 years and older, either sex
Mild to moderate COPD (FEV1/Forced vital capacity (FVC) ratio ≤ 0.70, FEV1 30-70% predicted, Diffusing capacity of the lungs for carbon monoxide (DLCO) ≥35% predicted)
On stable maintenance therapy for 2 months
Current or former smoker (patient report of at least a 10 pack-year history)
Ability to understand and willingness to sign consent documents

Exclusion Criteria

COPD exacerbation requiring treatment within past 6 weeks
Untreated arterial hypertension (systolic blood pressure > 140 mm Hg, diastolic blood pressure > 90 mm Hg)
Decompensated heart failure
Myocardial infarction within past 3 months or ever
Evidence of interstitial, occupational or chronic infectious lung disease
Renal dysfunction
Supplemental oxygen > 2 liters/m at rest
Failure to keep screening appointments

Primary Outcome Measures

Name	Time	Method
Establish a screening evaluation or characterization	Determined during screening clinical visit	We are doing the present study to identify people to include in a database who are age 40 and older with mild to moderate COPD and who will qualify for studies of COPD. The study will include establishing a screening evaluation or characterization for the following three studies. * Emphysema Progression in COPD- Losartan's Effects on Airway Parameters - NA_00009980 * Sleep-Related Physiology and Inflammation in Chronic Obstructive Pulmonary Disease - NA_00001771 * Genetic Epidemiology of Chronic Obstructive Pulmonary Disease - NA_00011524

Secondary Outcome Measures

Name	Time	Method

Locations (1): Johns Hopkins Asthma and Allergy Center
🇺🇸
Baltimore, Maryland, United States

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